拓扑数据分析（TDA）研究数据的形状模式。持续同源性（pH）是TDA中广泛使用的方法，其总结了多个尺度的数据的同源特征，并将它们存储在持久图（PDS）中。在本文中，我们提出了一种随机持久性图（RPDG）方法，其生成从数据产生的那些随机PDS序列。RPDG由（i）基于对持久性图推断的成对交互点处理的模型，并通过可逆跳转马克可蒙特卡罗（RJ-MCMC）算法来生成PDS样本。基于合成数据集的第一示例演示了RPDG的功效，并提供了与用于采样PDS的其他现有方法的详细比较。第二个例子演示了RPDG求解材料科学问题的效用，给出了小样本大小的真实数据集。

Customers are rapidly turning to social media for customer support. While brand agents on these platforms are motivated and well-intentioned to help and engage with customers, their efforts are often ignored if their initial response to the customer does not match a specific tone, style, or topic the customer is aiming to receive. The length of a conversation can reflect the effort and quality of the initial response made by a brand toward collaborating and helping consumers, even when the overall sentiment of the conversation might not be very positive. Thus, through this study, we aim to bridge this critical gap in the existing literature by analyzing language's content and stylistic aspects such as expressed empathy, psycho-linguistic features, dialogue tags, and metrics for quantifying personalization of the utterances that can influence the engagement of an interaction. This paper demonstrates that we can predict engagement using initial customer and brand posts.

Objective. The impact of social determinants of health (SDoH) on patients' healthcare quality and the disparity is well-known. Many SDoH items are not coded in structured forms in electronic health records. These items are often captured in free-text clinical notes, but there are limited methods for automatically extracting them. We explore a multi-stage pipeline involving named entity recognition (NER), relation classification (RC), and text classification methods to extract SDoH information from clinical notes automatically. Materials and Methods. The study uses the N2C2 Shared Task data, which was collected from two sources of clinical notes: MIMIC-III and University of Washington Harborview Medical Centers. It contains 4480 social history sections with full annotation for twelve SDoHs. In order to handle the issue of overlapping entities, we developed a novel marker-based NER model. We used it in a multi-stage pipeline to extract SDoH information from clinical notes. Results. Our marker-based system outperformed the state-of-the-art span-based models at handling overlapping entities based on the overall Micro-F1 score performance. It also achieved state-of-the-art performance compared to the shared task methods. Conclusion. The major finding of this study is that the multi-stage pipeline effectively extracts SDoH information from clinical notes. This approach can potentially improve the understanding and tracking of SDoHs in clinical settings. However, error propagation may be an issue, and further research is needed to improve the extraction of entities with complex semantic meanings and low-resource entities using external knowledge.

Objective. Chemical named entity recognition (NER) models have the potential to impact a wide range of downstream tasks, from identifying adverse drug reactions to general pharmacoepidemiology. However, it is unknown whether these models work the same for everyone. Performance disparities can potentially cause harm rather than the intended good. Hence, in this paper, we measure gender-related performance disparities of chemical NER systems. Materials and Methods. We develop a framework to measure gender bias in chemical NER models using synthetic data and a newly annotated dataset of over 92,405 words with self-identified gender information from Reddit. We applied and evaluated state-of-the-art biomedical NER models. Results. Our findings indicate that chemical NER models are biased. The results of the bias tests on the synthetic dataset and the real-world data multiple fairness issues. For example, for synthetic data, we find that female-related names are generally classified as chemicals, particularly in datasets containing many brand names rather than standard ones. For both datasets, we find consistent fairness issues resulting in substantial performance disparities between female- and male-related data. Discussion. Our study highlights the issue of biases in chemical NER models. For example, we find that many systems cannot detect contraceptives (e.g., birth control). Conclusion. Chemical NER models are biased and can be harmful to female-related groups. Therefore, practitioners should carefully consider the potential biases of these models and take steps to mitigate them.

We present Azimuth, an open-source and easy-to-use tool to perform error analysis for text classification. Compared to other stages of the ML development cycle, such as model training and hyper-parameter tuning, the process and tooling for the error analysis stage are less mature. However, this stage is critical for the development of reliable and trustworthy AI systems. To make error analysis more systematic, we propose an approach comprising dataset analysis and model quality assessment, which Azimuth facilitates. We aim to help AI practitioners discover and address areas where the model does not generalize by leveraging and integrating a range of ML techniques, such as saliency maps, similarity, uncertainty, and behavioral analyses, all in one tool. Our code and documentation are available at github.com/servicenow/azimuth.

Intensive Care in-hospital mortality prediction has various clinical applications. Neural prediction models, especially when capitalising on clinical notes, have been put forward as improvement on currently existing models. However, to be acceptable these models should be performant and transparent. This work studies different attention mechanisms for clinical neural prediction models in terms of their discrimination and calibration. Specifically, we investigate sparse attention as an alternative to dense attention weights in the task of in-hospital mortality prediction from clinical notes. We evaluate the attention mechanisms based on: i) local self-attention over words in a sentence, and ii) global self-attention with a transformer architecture across sentences. We demonstrate that the sparse mechanism approach outperforms the dense one for the local self-attention in terms of predictive performance with a publicly available dataset, and puts higher attention to prespecified relevant directive words. The performance at the sentence level, however, deteriorates as sentences including the influential directive words tend to be dropped all together.

Multilingual Neural Machine Translation (MNMT) models leverage many language pairs during training to improve translation quality for low-resource languages by transferring knowledge from high-resource languages. We study the quality of a domain-adapted MNMT model in the medical domain for English-Romanian with automatic metrics and a human error typology annotation which includes terminology-specific error categories. We compare the out-of-domain MNMT with the in-domain adapted MNMT. The in-domain MNMT model outperforms the out-of-domain MNMT in all measured automatic metrics and produces fewer terminology errors.

Neural models, with their ability to provide novel representations, have shown promising results in prediction tasks in healthcare. However, patient demographics, medical technology, and quality of care change over time. This often leads to drop in the performance of neural models for prospective patients, especially in terms of their calibration. The deep kernel learning (DKL) framework may be robust to such changes as it combines neural models with Gaussian processes, which are aware of prediction uncertainty. Our hypothesis is that out-of-distribution test points will result in probabilities closer to the global mean and hence prevent overconfident predictions. This in turn, we hypothesise, will result in better calibration on prospective data. This paper investigates DKL's behaviour when facing a temporal shift, which was naturally introduced when an information system that feeds a cohort database was changed. We compare DKL's performance to that of a neural baseline based on recurrent neural networks. We show that DKL indeed produced superior calibrated predictions. We also confirm that the DKL's predictions were indeed less sharp. In addition, DKL's discrimination ability was even improved: its AUC was 0.746 (+- 0.014 std), compared to 0.739 (+- 0.028 std) for the baseline. The paper demonstrated the importance of including uncertainty in neural computing, especially for their prospective use.

Automatic sign language processing is gaining popularity in Natural Language Processing (NLP) research (Yin et al., 2021). In machine translation (MT) in particular, sign language translation based on glosses is a prominent approach. In this paper, we review recent works on neural gloss translation. We find that limitations of glosses in general and limitations of specific datasets are not discussed in a transparent manner and that there is no common standard for evaluation. To address these issues, we put forward concrete recommendations for future research on gloss translation. Our suggestions advocate awareness of the inherent limitations of gloss-based approaches, realistic datasets, stronger baselines and convincing evaluation.

Machine-Learned Likelihoods (MLL) is a method that, by combining modern machine-learning classification techniques with likelihood-based inference tests, allows to estimate the experimental sensitivity of high-dimensional data sets. We extend the MLL method by including the exclusion hypothesis tests and show that the addition of Kernel Density Estimators avoids the need to bin the classifier output in order to extract the resulting one-dimensional signal and background probability density functions. We first test our method on toy models generated with multivariate Gaussian distributions, where the true probability distribution functions are known. We then apply it to a case of interest in the search for new physics at the HL-LHC, in which a $Z^\prime$ boson decays into lepton pairs, comparing the performance of our method for estimating 95\% CL exclusion limits to the results obtained applying a binned likelihood to the machine-learning classifier output.