外围插入的中央导管(PICC)由于其长期的血管内渗透感具有低感染率,因此已被广泛用作代表性的中央静脉线(CVC)之一。但是,PICC的尖端错位频率很高,增加了刺穿,栓塞和心律不齐等并发症的风险。为了自动,精确地检测到它,使用最新的深度学习(DL)技术进行了各种尝试。但是,即使采用了这些方法,实际上仍然很难确定尖端位置,因为多个片段现象(MFP)发生在预测和提取PICC线之前预测尖端之前所需的PICC线的过程。这项研究旨在开发一种通常应用于现有模型的系统,并通过删除模型输出的MF来更准确地恢复PICC线路,从而精确地定位了检测其处置的实际尖端位置。为此,我们提出了一个基于多阶段DL的框架后处理,以后处理现有技术的PICC线提取结果。根据是否将MFCN应用于五个常规模型,将每个均方根误差(RMSE)和MFP发病率比较性能。在内部验证中,当将MFCN应用于现有单个模型时,MFP平均提高了45%。 RMSE从平均26.85mm(17.16至35.80mm)到9.72mm(9.37至10.98mm)的平均增长了63%以上。在外部验证中,当应用MFCN时,MFP的发病率平均下降32%,RMSE平均下降了65 \%。因此,通过应用提出的MFCN,我们观察到与现有模型相比,PICC尖端位置的显着/一致检测性能提高。
translated by 谷歌翻译
人类生理学中的各种结构遵循特异性形态,通常在非常细的尺度上表达复杂性。这种结构的例子是胸前气道,视网膜血管和肝血管。可以观察到可以观察到可以观察到可以观察到可以观察到空间排列的磁共振成像(MRI),计算机断层扫描(CT),光学相干断层扫描(OCT)等医学成像模式(MRI),计算机断层扫描(CT),可以观察到空间排列的大量2D和3D图像的集合。这些结构在医学成像中的分割非常重要,因为对结构的分析提供了对疾病诊断,治疗计划和预后的见解。放射科医生手动标记广泛的数据通常是耗时且容易出错的。结果,在过去的二十年中,自动化或半自动化的计算模型已成为医学成像的流行研究领域,迄今为止,许多计算模型已经开发出来。在这项调查中,我们旨在对当前公开可用的数据集,细分算法和评估指标进行全面审查。此外,讨论了当前的挑战和未来的研究方向。
translated by 谷歌翻译
机器学习和计算机视觉技术近年来由于其自动化,适合性和产生惊人结果的能力而迅速发展。因此,在本文中,我们调查了2014年至2022年之间发表的关键研究,展示了不同的机器学习算法研究人员用来分割肝脏,肝肿瘤和肝脉管结构的研究。我们根据感兴趣的组织(肝果,肝肿瘤或肝毒剂)对被调查的研究进行了划分,强调了同时解决多个任务的研究。此外,机器学习算法被归类为受监督或无监督的,如果属于某个方案的工作量很大,则将进一步分区。此外,对文献和包含上述组织面具的网站发现的不同数据集和挑战进行了彻底讨论,强调了组织者的原始贡献和其他研究人员的贡献。同样,在我们的评论中提到了文献中过度使用的指标,这强调了它们与手头的任务的相关性。最后,强调创新研究人员应对需要解决的差距的关键挑战和未来的方向,例如许多关于船舶分割挑战的研究的稀缺性以及为什么需要早日处理他们的缺席。
translated by 谷歌翻译
X-ray imaging technology has been used for decades in clinical tasks to reveal the internal condition of different organs, and in recent years, it has become more common in other areas such as industry, security, and geography. The recent development of computer vision and machine learning techniques has also made it easier to automatically process X-ray images and several machine learning-based object (anomaly) detection, classification, and segmentation methods have been recently employed in X-ray image analysis. Due to the high potential of deep learning in related image processing applications, it has been used in most of the studies. This survey reviews the recent research on using computer vision and machine learning for X-ray analysis in industrial production and security applications and covers the applications, techniques, evaluation metrics, datasets, and performance comparison of those techniques on publicly available datasets. We also highlight some drawbacks in the published research and give recommendations for future research in computer vision-based X-ray analysis.
translated by 谷歌翻译
Indonesia holds the second-highest-ranking country for the highest number of malaria cases in Southeast Asia. A different malaria parasite semantic segmentation technique based on a deep learning approach is an alternative to reduce the limitations of traditional methods. However, the main problem of the semantic segmentation technique is raised since large parasites are dominant, and the tiny parasites are suppressed. In addition, the amount and variance of data are important influences in establishing their models. In this study, we conduct two contributions. First, we collect 559 microscopic images containing 691 malaria parasites of thin blood smears. The dataset is named PlasmoID, and most data comes from rural Indonesia. PlasmoID also provides ground truth for parasite detection and segmentation purposes. Second, this study proposes a malaria parasite segmentation and detection scheme by combining Faster RCNN and a semantic segmentation technique. The proposed scheme has been evaluated on the PlasmoID dataset. It has been compared with recent studies of semantic segmentation techniques, namely UNet, ResFCN-18, DeepLabV3, DeepLabV3plus and ResUNet-18. The result shows that our proposed scheme can improve the segmentation and detection of malaria parasite performance compared to original semantic segmentation techniques.
translated by 谷歌翻译
视网膜脉管系统的研究是筛查和诊断许多疾病的基本阶段。完整的视网膜血管分析需要将视网膜的血管分为动脉和静脉(A/V)。早期自动方法在两个顺序阶段接近这些分割和分类任务。但是,目前,这些任务是作为联合语义分割任务处理的,因为分类结果在很大程度上取决于血管分割的有效性。在这方面,我们提出了一种新的方法,用于从眼睛眼睛图像中对视网膜A/V进行分割和分类。特别是,我们提出了一种新颖的方法,该方法与以前的方法不同,并且由于新的损失,将联合任务分解为针对动脉,静脉和整个血管树的三个分割问题。这种配置允许直观地处理容器交叉口,并直接提供不同靶血管树的精确分割罩。提供的关于公共视网膜图血管树提取(RITE)数据集的消融研究表明,所提出的方法提供了令人满意的性能,尤其是在不同结构的分割中。此外,与最新技术的比较表明,我们的方法在A/V分类中获得了高度竞争的结果,同时显着改善了血管分割。提出的多段方法允许检测更多的血管,并更好地分割不同的结构,同时实现竞争性分类性能。同样,用这些术语来说,我们的方法优于各种参考作品的方法。此外,与以前的方法相比,该方法允许直接检测到容器交叉口,并在这些复杂位置保留A/V的连续性。
translated by 谷歌翻译
心肌活力的评估对于患有心肌梗塞的患者的诊断和治疗管理是必不可少的,并且心肌病理学的分类是本评估的关键。这项工作定义了医学图像分析的新任务,即进行心肌病理分割(MYOPS)结合三个序列的心脏磁共振(CMR)图像,该图像首次与Mycai 2020一起在Myops挑战中提出的。挑战提供了45个配对和预对准的CMR图像,允许算法将互补信息与三个CMR序列组合到病理分割。在本文中,我们提供了挑战的详细信息,从十五个参与者的作品调查,并根据五个方面解释他们的方法,即预处理,数据增强,学习策略,模型架构和后处理。此外,我们对不同因素的结果分析了结果,以检查关键障碍和探索解决方案的潜力,以及为未来的研究提供基准。我们得出结论,虽然报告了有前途的结果,但研究仍处于早期阶段,在成功应用于诊所之前需要更深入的探索。请注意,MyOPS数据和评估工具继续通过其主页(www.sdspeople.fudan.edu.cn/zhuangxiahai/0/myops20 /)注册注册。
translated by 谷歌翻译
随着深度学习方法的进步,如深度卷积神经网络,残余神经网络,对抗网络的进步。 U-Net架构最广泛利用生物医学图像分割,以解决目标区域或子区域的识别和检测的自动化。在最近的研究中,基于U-Net的方法在不同应用中显示了最先进的性能,以便在脑肿瘤,肺癌,阿尔茨海默,乳腺癌等疾病的早期诊断和治疗中发育计算机辅助诊断系统等,使用各种方式。本文通过描述U-Net框架来提出这些方法的成功,然后通过执行1)型号的U-Net变体进行综合分析,2)模特内分类,建立更好的见解相关的挑战和解决方案。此外,本文还强调了基于U-Net框架在持续的大流行病,严重急性呼吸综合征冠状病毒2(SARS-COV-2)中的贡献也称为Covid-19。最后,分析了这些U-Net变体的优点和相似性以及生物医学图像分割所涉及的挑战,以发现该领域的未来未来的研究方向。
translated by 谷歌翻译
最近关于Covid-19的研究表明,CT成像提供了评估疾病进展和协助诊断的有用信息,以及帮助理解疾病。有越来越多的研究,建议使用深度学习来使用胸部CT扫描提供快速准确地定量Covid-19。兴趣的主要任务是胸部CT扫描的肺和肺病变的自动分割,确认或疑似Covid-19患者。在这项研究中,我们使用多中心数据集比较12个深度学习算法,包括开源和内部开发的算法。结果表明,合并不同的方法可以提高肺部分割,二元病变分割和多种子病变分割的总体测试集性能,从而分别为0.982,0.724和0.469的平均骰子分别。将得到的二元病变分段为91.3ml的平均绝对体积误差。通常,区分不同病变类型的任务更加困难,分别具有152mL的平均绝对体积差,分别为整合和磨碎玻璃不透明度为0.369和0.523的平均骰子分数。所有方法都以平均体积误差进行二元病变分割,该分段优于人类评估者的视觉评估,表明这些方法足以用于临床实践中使用的大规模评估。
translated by 谷歌翻译
肺癌是最致命的癌症之一,部分诊断和治疗取决于肿瘤的准确描绘。目前是最常见的方法的人以人为本的分割,须遵守观察者间变异性,并且考虑到专家只能提供注释的事实,也是耗时的。最近展示了有前途的结果,自动和半自动肿瘤分割方法。然而,随着不同的研究人员使用各种数据集和性能指标验证了其算法,可靠地评估这些方法仍然是一个开放的挑战。通过2018年IEEE视频和图像处理(VIP)杯竞赛创建的计算机断层摄影扫描(LOTUS)基准测试的肺起源肿瘤分割的目标是提供唯一的数据集和预定义的指标,因此不同的研究人员可以开发和以统一的方式评估他们的方法。 2018年VIP杯始于42个国家的全球参与,以获得竞争数据。在注册阶段,有129名成员组成了来自10个国家的28个团队,其中9个团队将其达到最后阶段,6队成功完成了所有必要的任务。简而言之,竞争期间提出的所有算法都是基于深度学习模型与假阳性降低技术相结合。三种决赛选手开发的方法表明,有希望的肿瘤细分导致导致越来越大的努力应降低假阳性率。本次竞争稿件概述了VIP-Cup挑战,以及所提出的算法和结果。
translated by 谷歌翻译
大脑的血管为人脑提供所需的营养和氧气。作为大脑血液供应的脆弱部分,小血管的病理可能会引起严重的问题,例如脑小血管疾病(CSVD)。还显示CSVD与神经变性有关,例如阿尔茨海默氏病。随着7个特斯拉MRI系统的发展,可以实现较高的空间图像分辨率,从而使大脑中非常小的血管描绘。非深度学习的方法进行血管分割的方法,例如,弗兰吉的血管增强,随后的阈值能够将培养基分割至大容器,但通常无法分割小血管。这些方法对小容器的敏感性可以通过广泛的参数调整或手动校正来提高,尽管使它们耗时,费力,并且对于较大的数据集而言是不可行的。本文提出了一个深度学习架构,以自动在7特斯拉3D飞行时间(TOF)磁共振血管造影(MRA)数据中自动分割小血管。该算法对仅11个受试者的小型半自动分段数据进行训练和评估;使用六个进行培训,两个进行验证,三个进行测试。基于U-NET多尺度监督的深度学习模型使用训练子集进行了训练,并以一种自我监督的方式使用变形 - 意识到的学习以改善概括性能。针对测试集对拟议的技术进行了定量和定性评估,并获得了80.44 $ \ pm $ 0.83的骰子得分。此外,将所提出的方法的结果与选定的手动分割区域(62.07结果骰子)进行了比较,并通过变形感知的学习显示出显着改善(18.98 \%)。
translated by 谷歌翻译
自动识别基础心脏异常的结构底物可以潜在地为介入程序提供实时指导。有了心脏组织底物的了解,可以通过检测心律不齐的底物来进一步优化复杂的心律不齐和心室心动过速等复杂的心律不齐和心室心动过速。光学相干断层扫描(OCT)是一种实时成像方式,有助于满足这一需求。心脏图像分析的现有方法主要依赖于完全监督的学习技术,这些技术遇到了在像素标签的劳动密集型注释过程中工作量的缺点。为了减少对像素标签的需求,我们使用人类心脏底物的OCT图像上的图像级注释开发了一个两阶段的深度学习框架,用于心脏脂肪组织分割。特别是,我们将类激活映射与超像素分割整合在一起,以解决心脏组织分割中提出的稀疏组织种子挑战。我们的研究弥合了自动组织分析的需求与缺乏高质量像素的注释之间的差距。据我们所知,这是第一项尝试通过弱监督的学习技术来解决OCT图像上心脏组织分割的研究。在体外人类心脏OCT数据集中,我们证明了我们对图像级注释的弱监督方法可与对像素式注释进行训练的完全监督方法相当。
translated by 谷歌翻译
组织学图像中核和腺体的实例分割是用于癌症诊断,治疗计划和生存分析的计算病理学工作流程中的重要一步。随着现代硬件的出现,大规模质量公共数据集的最新可用性以及社区组织的宏伟挑战已经看到了自动化方法的激增,重点是特定领域的挑战,这对于技术进步和临床翻译至关重要。在这项调查中,深入分析了过去五年(2017-2022)中发表的原子核和腺体实例细分的126篇论文,进行了深入分析,讨论了当前方法的局限性和公开挑战。此外,提出了潜在的未来研究方向,并总结了最先进方法的贡献。此外,还提供了有关公开可用数据集的概括摘要以及关于说明每种挑战的最佳性能方法的巨大挑战的详细见解。此外,我们旨在使读者现有研究的现状和指针在未来的发展方向上开发可用于临床实践的方法,从而可以改善诊断,分级,预后和癌症的治疗计划。据我们所知,以前没有工作回顾了朝向这一方向的组织学图像中的实例细分。
translated by 谷歌翻译
Pneumonia, a respiratory infection brought on by bacteria or viruses, affects a large number of people, especially in developing and impoverished countries where high levels of pollution, unclean living conditions, and overcrowding are frequently observed, along with insufficient medical infrastructure. Pleural effusion, a condition in which fluids fill the lung and complicate breathing, is brought on by pneumonia. Early detection of pneumonia is essential for ensuring curative care and boosting survival rates. The approach most usually used to diagnose pneumonia is chest X-ray imaging. The purpose of this work is to develop a method for the automatic diagnosis of bacterial and viral pneumonia in digital x-ray pictures. This article first presents the authors' technique, and then gives a comprehensive report on recent developments in the field of reliable diagnosis of pneumonia. In this study, here tuned a state-of-the-art deep convolutional neural network to classify plant diseases based on images and tested its performance. Deep learning architecture is compared empirically. VGG19, ResNet with 152v2, Resnext101, Seresnet152, Mobilenettv2, and DenseNet with 201 layers are among the architectures tested. Experiment data consists of two groups, sick and healthy X-ray pictures. To take appropriate action against plant diseases as soon as possible, rapid disease identification models are preferred. DenseNet201 has shown no overfitting or performance degradation in our experiments, and its accuracy tends to increase as the number of epochs increases. Further, DenseNet201 achieves state-of-the-art performance with a significantly a smaller number of parameters and within a reasonable computing time. This architecture outperforms the competition in terms of testing accuracy, scoring 95%. Each architecture was trained using Keras, using Theano as the backend.
translated by 谷歌翻译
慢性伤口显着影响生活质量。如果没有正确管理,他们可能会严重恶化。基于图像的伤口分析可以通过量化与愈合相关的重要特征来客观地评估伤口状态。然而,伤口类型,图像背景组成和捕获条件的高异质性挑战伤口图像的鲁棒分割。我们呈现了检测和段(DS),深度学习方法,以产生具有高泛化能力的伤口分割图。在我们的方法中,专门的深度神经网络检测到伤口位置,从未经信息背景隔离伤口,并计算伤口分割图。我们使用具有糖尿病脚溃疡图像的一个数据集评估了这种方法。为了进一步测试,使用4个补充独立数据组,具有来自不同体积的较大种类的伤口类型。当以相同的方法组合检测和分割时,在将完整图像上的分割到0.85时,Matthews的相关系数(MCC)从0.29提高到0.29。当从补充数据集汲取的卷绕图像上进行测试时,DS方法将平均MCC从0.17增加到0.85。此外,DS方法使得分段模型的培训能够在保持分割性能的同时培训高达90%的训练数据。
translated by 谷歌翻译
In medical image analysis, automated segmentation of multi-component anatomical structures, which often have a spectrum of potential anomalies and pathologies, is a challenging task. In this work, we develop a multi-step approach using U-Net-based neural networks to initially detect anomalies (bone marrow lesions, bone cysts) in the distal femur, proximal tibia and patella from 3D magnetic resonance (MR) images of the knee in individuals with varying grades of osteoarthritis. Subsequently, the extracted data are used for downstream tasks involving semantic segmentation of individual bone and cartilage volumes as well as bone anomalies. For anomaly detection, the U-Net-based models were developed to reconstruct the bone profiles of the femur and tibia in images via inpainting so anomalous bone regions could be replaced with close to normal appearances. The reconstruction error was used to detect bone anomalies. A second anomaly-aware network, which was compared to anomaly-na\"ive segmentation networks, was used to provide a final automated segmentation of the femoral, tibial and patellar bones and cartilages from the knee MR images containing a spectrum of bone anomalies. The anomaly-aware segmentation approach provided up to 58% reduction in Hausdorff distances for bone segmentations compared to the results from the anomaly-na\"ive segmentation networks. In addition, the anomaly-aware networks were able to detect bone lesions in the MR images with greater sensitivity and specificity (area under the receiver operating characteristic curve [AUC] up to 0.896) compared to the anomaly-na\"ive segmentation networks (AUC up to 0.874).
translated by 谷歌翻译
To analyze this characteristic of vulnerability, we developed an automated deep learning method for detecting microvessels in intravascular optical coherence tomography (IVOCT) images. A total of 8,403 IVOCT image frames from 85 lesions and 37 normal segments were analyzed. Manual annotation was done using a dedicated software (OCTOPUS) previously developed by our group. Data augmentation in the polar (r,{\theta}) domain was applied to raw IVOCT images to ensure that microvessels appear at all possible angles. Pre-processing methods included guidewire/shadow detection, lumen segmentation, pixel shifting, and noise reduction. DeepLab v3+ was used to segment microvessel candidates. A bounding box on each candidate was classified as either microvessel or non-microvessel using a shallow convolutional neural network. For better classification, we used data augmentation (i.e., angle rotation) on bounding boxes with a microvessel during network training. Data augmentation and pre-processing steps improved microvessel segmentation performance significantly, yielding a method with Dice of 0.71+/-0.10 and pixel-wise sensitivity/specificity of 87.7+/-6.6%/99.8+/-0.1%. The network for classifying microvessels from candidates performed exceptionally well, with sensitivity of 99.5+/-0.3%, specificity of 98.8+/-1.0%, and accuracy of 99.1+/-0.5%. The classification step eliminated the majority of residual false positives, and the Dice coefficient increased from 0.71 to 0.73. In addition, our method produced 698 image frames with microvessels present, compared to 730 from manual analysis, representing a 4.4% difference. When compared to the manual method, the automated method improved microvessel continuity, implying improved segmentation performance. The method will be useful for research purposes as well as potential future treatment planning.
translated by 谷歌翻译
深度学习已被广​​泛用于医学图像分割,并且录制了录制了该领域深度学习的成功的大量论文。在本文中,我们使用深层学习技术对医学图像分割的全面主题调查。本文进行了两个原创贡献。首先,与传统调查相比,直接将深度学习的文献分成医学图像分割的文学,并为每组详细介绍了文献,我们根据从粗略到精细的多级结构分类目前流行的文献。其次,本文侧重于监督和弱监督的学习方法,而不包括无监督的方法,因为它们在许多旧调查中引入而且他们目前不受欢迎。对于监督学习方法,我们分析了三个方面的文献:骨干网络的选择,网络块的设计,以及损耗功能的改进。对于虚弱的学习方法,我们根据数据增强,转移学习和交互式分割进行调查文献。与现有调查相比,本调查将文献分类为比例不同,更方便读者了解相关理由,并将引导他们基于深度学习方法思考医学图像分割的适当改进。
translated by 谷歌翻译
晚期钆增强磁共振成像(LGE MRI)通常用于可视化和量化左心房(LA)疤痕。疤痕的位置和程度提供了心理生理学和心房颤动进展的重要信息(AF)。因此,LGE MRI的La Scar分段和量化可用于AF患者的计算机辅助诊断和治疗分层。由于手动描绘可能是耗时的,并且经过专家内和专家间变异性,因此非常需要自动化这种计算,这然而仍然仍然具有挑战性和研究。本文旨在为La腔,墙壁,瘢痕和消融差距分割和LGE MRI的定量提供系统审查,以及AF研究的相关文献。具体而言,我们首先总结AF相关的成像技术,特别是LGE MRI。然后,我们详细介绍了四个计算任务的方法,并总结了每个任务中应用的验证策略。最后,概述了未来可能的未来发展,简要调查了上述方法的潜在临床应用。审查表明,该主题的研究仍处于早期阶段。虽然已经提出了几种方法,但特别是对于LA分割,由于与图像采集的高度变化相关的性能问题和图像采集差异有关的性能问题,仍有很大的算法发展。
translated by 谷歌翻译
Solving variational image segmentation problems with hidden physics is often expensive and requires different algorithms and manually tunes model parameter. The deep learning methods based on the U-Net structure have obtained outstanding performances in many different medical image segmentation tasks, but designing such networks requires a lot of parameters and training data, not always available for practical problems. In this paper, inspired by traditional multi-phase convexity Mumford-Shah variational model and full approximation scheme (FAS) solving the nonlinear systems, we propose a novel variational-model-informed network (denoted as FAS-Unet) that exploits the model and algorithm priors to extract the multi-scale features. The proposed model-informed network integrates image data and mathematical models, and implements them through learning a few convolution kernels. Based on the variational theory and FAS algorithm, we first design a feature extraction sub-network (FAS-Solution module) to solve the model-driven nonlinear systems, where a skip-connection is employed to fuse the multi-scale features. Secondly, we further design a convolution block to fuse the extracted features from the previous stage, resulting in the final segmentation possibility. Experimental results on three different medical image segmentation tasks show that the proposed FAS-Unet is very competitive with other state-of-the-art methods in qualitative, quantitative and model complexity evaluations. Moreover, it may also be possible to train specialized network architectures that automatically satisfy some of the mathematical and physical laws in other image problems for better accuracy, faster training and improved generalization.The code is available at \url{https://github.com/zhuhui100/FASUNet}.
translated by 谷歌翻译