如今，越来越多的人被诊断出患有心血管疾病（CVD），这是全球死亡的主要原因。鉴定这些心脏问题的金标准是通过心电图（ECG）。标准的12铅ECG广泛用于临床实践和当前的大多数研究。但是，使用较少的铅可以使ECG更加普遍，因为它可以与便携式或可穿戴设备集成。本文介绍了两种新型技术，以提高当前深度学习系统的3铅ECG分类的性能，从而与使用标准12铅ECG训练的模型相提并论。具体而言，我们提出了一种以心跳回归数量的形式的多任务学习方案，以及将患者人口统计数据整合到系统中的有效机制。随着这两个进步，我们在两个大规模的ECG数据集（即Chapman和CPSC-2018）上以F1分数为0.9796和0.8140的分类性能，这些数据分别超过了当前最新的ECG分类方法，该方法超过了当前的ECG分类方法。甚至那些接受了12条铅数据的培训。为了鼓励进一步开发，我们的源代码可在https://github.com/lhkhiem28/lightx3ecg上公开获得。

心血管疾病（CVD）是一组心脏和血管疾病，是对人类健康最严重的危险之一，此类患者的数量仍在增长。早期，准确的检测在成功治疗和干预中起着关键作用。心电图（ECG）是识别各种心血管异常的金标准。在临床实践和当前大多数研究中，主要使用标准的12铅ECG。但是，使用较少的铅可以使ECG更加普遍，因为可以通过便携式或可穿戴设备来方便地记录它。在这项研究中，我们开发了一种新颖的深度学习系统，以仅使用三个ECG铅来准确识别多个心血管异常。

端到端的口语理解（SLU）使用单个模型直接从音频中预测意图。它有望通过利用中间文本表示中丢失的声学信息来提高助手系统的性能，并防止自动语音识别（ASR）中的级联错误。此外，在部署助手系统时，拥有一个统一模型具有效率优势。但是，具有语义解析标签的公共音频数据集有限的数量阻碍了该领域的研究进展。在本文中，我们发布了以任务为导向的语义解析（Stop）数据集，该数据集是公开可用的最大，最复杂的SLU数据集。此外，我们定义了低资源拆分，以建立有限的标记数据时改善SLU的基准。此外，除了人类录制的音频外，我们还发布了TTS生成版本，以基于端到端SLU系统的低资源域适应性的性能。最初的实验表明，端到端SLU模型的性能比级联的同行差一些，我们希望这能鼓励未来的工作。

Diabetic Retinopathy (DR) is a leading cause of vision loss in the world, and early DR detection is necessary to prevent vision loss and support an appropriate treatment. In this work, we leverage interactive machine learning and introduce a joint learning framework, termed DRG-Net, to effectively learn both disease grading and multi-lesion segmentation. Our DRG-Net consists of two modules: (i) DRG-AI-System to classify DR Grading, localize lesion areas, and provide visual explanations; (ii) DRG-Expert-Interaction to receive feedback from user-expert and improve the DRG-AI-System. To deal with sparse data, we utilize transfer learning mechanisms to extract invariant feature representations by using Wasserstein distance and adversarial learning-based entropy minimization. Besides, we propose a novel attention strategy at both low- and high-level features to automatically select the most significant lesion information and provide explainable properties. In terms of human interaction, we further develop DRG-Net as a tool that enables expert users to correct the system's predictions, which may then be used to update the system as a whole. Moreover, thanks to the attention mechanism and loss functions constraint between lesion features and classification features, our approach can be robust given a certain level of noise in the feedback of users. We have benchmarked DRG-Net on the two largest DR datasets, i.e., IDRID and FGADR, and compared it to various state-of-the-art deep learning networks. In addition to outperforming other SOTA approaches, DRG-Net is effectively updated using user feedback, even in a weakly-supervised manner.

Summary quality assessment metrics have two categories: reference-based and reference-free. Reference-based metrics are theoretically more accurate but are limited by the availability and quality of the human-written references, which are both difficulty to ensure. This inspires the development of reference-free metrics, which are independent from human-written references, in the past few years. However, existing reference-free metrics cannot be both zero-shot and accurate. In this paper, we propose a zero-shot but accurate reference-free approach in a sneaky way: feeding documents, based upon which summaries generated, as references into reference-based metrics. Experimental results show that this zero-shot approach can give us the best-performing reference-free metrics on nearly all aspects on several recently-released datasets, even beating reference-free metrics specifically trained for this task sometimes. We further investigate what reference-based metrics can benefit from such repurposing and whether our additional tweaks help.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Non-invasive prostate cancer detection from MRI has the potential to revolutionize patient care by providing early detection of clinically-significant disease (ISUP grade group >= 2), but has thus far shown limited positive predictive value. To address this, we present an MRI-based deep learning method for predicting clinically significant prostate cancer applicable to a patient population with subsequent ground truth biopsy results ranging from benign pathology to ISUP grade group~5. Specifically, we demonstrate that mixed supervision via diverse histopathological ground truth improves classification performance despite the cost of reduced concordance with image-based segmentation. That is, where prior approaches have utilized pathology results as ground truth derived from targeted biopsies and whole-mount prostatectomy to strongly supervise the localization of clinically significant cancer, our approach also utilizes weak supervision signals extracted from nontargeted systematic biopsies with regional localization to improve overall performance. Our key innovation is performing regression by distribution rather than simply by value, enabling use of additional pathology findings traditionally ignored by deep learning strategies. We evaluated our model on a dataset of 973 (testing n=160) multi-parametric prostate MRI exams collected at UCSF from 2015-2018 followed by MRI/ultrasound fusion (targeted) biopsy and systematic (nontargeted) biopsy of the prostate gland, demonstrating that deep networks trained with mixed supervision of histopathology can significantly exceed the performance of the Prostate Imaging-Reporting and Data System (PI-RADS) clinical standard for prostate MRI interpretation.

Establishing open and general benchmarks has been a critical driving force behind the success of modern machine learning techniques. As machine learning is being applied to broader domains and tasks, there is a need to establish richer and more diverse benchmarks to better reflect the reality of the application scenarios. Graph learning is an emerging field of machine learning that urgently needs more and better benchmarks. To accommodate the need, we introduce Graph Learning Indexer (GLI), a benchmark curation platform for graph learning. In comparison to existing graph learning benchmark libraries, GLI highlights two novel design objectives. First, GLI is designed to incentivize \emph{dataset contributors}. In particular, we incorporate various measures to minimize the effort of contributing and maintaining a dataset, increase the usability of the contributed dataset, as well as encourage attributions to different contributors of the dataset. Second, GLI is designed to curate a knowledge base, instead of a plain collection, of benchmark datasets. We use multiple sources of meta information to augment the benchmark datasets with \emph{rich characteristics}, so that they can be easily selected and used in downstream research or development. The source code of GLI is available at \url{https://github.com/Graph-Learning-Benchmarks/gli}.

Manually analyzing spermatozoa is a tremendous task for biologists due to the many fast-moving spermatozoa, causing inconsistencies in the quality of the assessments. Therefore, computer-assisted sperm analysis (CASA) has become a popular solution. Despite this, more data is needed to train supervised machine learning approaches in order to improve accuracy and reliability. In this regard, we provide a dataset called VISEM-Tracking with 20 video recordings of 30s of spermatozoa with manually annotated bounding-box coordinates and a set of sperm characteristics analyzed by experts in the domain. VISEM-Tracking is an extension of the previously published VISEM dataset. In addition to the annotated data, we provide unlabeled video clips for easy-to-use access and analysis of the data. As part of this paper, we present baseline sperm detection performances using the YOLOv5 deep learning model trained on the VISEM-Tracking dataset. As a result, the dataset can be used to train complex deep-learning models to analyze spermatozoa. The dataset is publicly available at https://zenodo.org/record/7293726.

Artificial intelligence methods including deep neural networks (DNN) can provide rapid molecular classification of tumors from routine histology with accuracy that matches or exceeds human pathologists. Discerning how neural networks make their predictions remains a significant challenge, but explainability tools help provide insights into what models have learned when corresponding histologic features are poorly defined. Here, we present a method for improving explainability of DNN models using synthetic histology generated by a conditional generative adversarial network (cGAN). We show that cGANs generate high-quality synthetic histology images that can be leveraged for explaining DNN models trained to classify molecularly-subtyped tumors, exposing histologic features associated with molecular state. Fine-tuning synthetic histology through class and layer blending illustrates nuanced morphologic differences between tumor subtypes. Finally, we demonstrate the use of synthetic histology for augmenting pathologist-in-training education, showing that these intuitive visualizations can reinforce and improve understanding of histologic manifestations of tumor biology.