基于深度学习的组织病理学图像分类是帮助医生提高癌症诊断的准确性和迅速性的关键技术。然而，在复杂的手动注释过程中，嘈杂的标签通常是不可避免的，因此误导了分类模型的培训。在这项工作中，我们介绍了一种用于组织病理学图像分类的新型硬样本感知噪声稳健学习方法。为了区分来自有害嘈杂的内容漏洞，我们通过使用样本培训历史来构建一个简单/硬/噪声（EHN）检测模型。然后，我们将EHN集成到自动训练架构中，通过逐渐校正降低噪声速率。通过获得的几乎干净的数据集，我们进一步提出了一种噪声抑制和硬增强（NSHE）方案来训练噪声鲁棒模型。与以前的作品相比，我们的方法可以节省更多清洁样本，并且可以直接应用于实际嘈杂的数据集场景，而无需使用清洁子集。实验结果表明，该方案在合成和现实世界嘈杂的数据集中优于当前最先进的方法。源代码和数据可在https://github.com/bupt-ai-cz/hsa-nrl/处获得。

目的：开发和验证基于临床阴性ALN的早期乳腺癌（EBC）术后预测腋窝淋巴结（ALN）转移的深度学习（DL）的主要肿瘤活检签名。方法：从2010年5月到2020年5月，共注册了1,058名具有病理证实ALN状态的eBC患者。基于关注的多实例学习（AMIL）框架，建立了一种DL核心针活检（DL-CNB）模型利用DL特征预测ALN状态，该DL特征从两位病理学家注释的乳腺CNB样本的数字化全幻灯片（WSIS）的癌症区域提取。分析了准确性，灵敏度，特异性，接收器操作特征（ROC）曲线和ROC曲线（AUC）下的区域进行评估，评估我们的模型。结果：具有VGG16_BN的最佳性DL-CNB模型作为特征提取器实现了0.816的AUC（95％置信区间（CI）：0.758,0.865），以预测独立测试队列的阳性Aln转移。此外，我们的模型包含称为DL-CNB + C的临床数据，得到了0.831的最佳精度（95％CI：0.775,0.878），特别是对于50岁以下的患者（AUC：0.918,95％CI： 0.825,0.971）。 DL-CNB模型的解释表明，最高度预测ALN转移的顶部签名的特征在于包括密度（$ P $ 0.015），周长（$ P $ 0.009），循环（$ P $ = 0.010）和方向（$ p $ = 0.012）。结论：我们的研究提供了一种基于DL的基于DL的生物标志物在原发性肿瘤CNB上，以预先验证EBC患者的术前预测ALN的转移状态。

Optical coherence tomography (OCT) captures cross-sectional data and is used for the screening, monitoring, and treatment planning of retinal diseases. Technological developments to increase the speed of acquisition often results in systems with a narrower spectral bandwidth, and hence a lower axial resolution. Traditionally, image-processing-based techniques have been utilized to reconstruct subsampled OCT data and more recently, deep-learning-based methods have been explored. In this study, we simulate reduced axial scan (A-scan) resolution by Gaussian windowing in the spectral domain and investigate the use of a learning-based approach for image feature reconstruction. In anticipation of the reduced resolution that accompanies wide-field OCT systems, we build upon super-resolution techniques to explore methods to better aid clinicians in their decision-making to improve patient outcomes, by reconstructing lost features using a pixel-to-pixel approach with an altered super-resolution generative adversarial network (SRGAN) architecture.

We introduce a new tool for stochastic convex optimization (SCO): a Reweighted Stochastic Query (ReSQue) estimator for the gradient of a function convolved with a (Gaussian) probability density. Combining ReSQue with recent advances in ball oracle acceleration [CJJJLST20, ACJJS21], we develop algorithms achieving state-of-the-art complexities for SCO in parallel and private settings. For a SCO objective constrained to the unit ball in $\mathbb{R}^d$, we obtain the following results (up to polylogarithmic factors). We give a parallel algorithm obtaining optimization error $\epsilon_{\text{opt}}$ with $d^{1/3}\epsilon_{\text{opt}}^{-2/3}$ gradient oracle query depth and $d^{1/3}\epsilon_{\text{opt}}^{-2/3} + \epsilon_{\text{opt}}^{-2}$ gradient queries in total, assuming access to a bounded-variance stochastic gradient estimator. For $\epsilon_{\text{opt}} \in [d^{-1}, d^{-1/4}]$, our algorithm matches the state-of-the-art oracle depth of [BJLLS19] while maintaining the optimal total work of stochastic gradient descent. We give an $(\epsilon_{\text{dp}}, \delta)$-differentially private algorithm which, given $n$ samples of Lipschitz loss functions, obtains near-optimal optimization error and makes $\min(n, n^2\epsilon_{\text{dp}}^2 d^{-1}) + \min(n^{4/3}\epsilon_{\text{dp}}^{1/3}, (nd)^{2/3}\epsilon_{\text{dp}}^{-1})$ queries to the gradients of these functions. In the regime $d \le n \epsilon_{\text{dp}}^{2}$, where privacy comes at no cost in terms of the optimal loss up to constants, our algorithm uses $n + (nd)^{2/3}\epsilon_{\text{dp}}^{-1}$ queries and improves recent advancements of [KLL21, AFKT21]. In the moderately low-dimensional setting $d \le \sqrt n \epsilon_{\text{dp}}^{3/2}$, our query complexity is near-linear.

Cashews are grown by over 3 million smallholders in more than 40 countries worldwide as a principal source of income. As the third largest cashew producer in Africa, Benin has nearly 200,000 smallholder cashew growers contributing 15% of the country's national export earnings. However, a lack of information on where and how cashew trees grow across the country hinders decision-making that could support increased cashew production and poverty alleviation. By leveraging 2.4-m Planet Basemaps and 0.5-m aerial imagery, newly developed deep learning algorithms, and large-scale ground truth datasets, we successfully produced the first national map of cashew in Benin and characterized the expansion of cashew plantations between 2015 and 2021. In particular, we developed a SpatioTemporal Classification with Attention (STCA) model to map the distribution of cashew plantations, which can fully capture texture information from discriminative time steps during a growing season. We further developed a Clustering Augmented Self-supervised Temporal Classification (CASTC) model to distinguish high-density versus low-density cashew plantations by automatic feature extraction and optimized clustering. Results show that the STCA model has an overall accuracy of 80% and the CASTC model achieved an overall accuracy of 77.9%. We found that the cashew area in Benin has doubled from 2015 to 2021 with 60% of new plantation development coming from cropland or fallow land, while encroachment of cashew plantations into protected areas has increased by 70%. Only half of cashew plantations were high-density in 2021, suggesting high potential for intensification. Our study illustrates the power of combining high-resolution remote sensing imagery and state-of-the-art deep learning algorithms to better understand tree crops in the heterogeneous smallholder landscape.

There are multiple scales of abstraction from which we can describe the same image, depending on whether we are focusing on fine-grained details or a more global attribute of the image. In brain mapping, learning to automatically parse images to build representations of both small-scale features (e.g., the presence of cells or blood vessels) and global properties of an image (e.g., which brain region the image comes from) is a crucial and open challenge. However, most existing datasets and benchmarks for neuroanatomy consider only a single downstream task at a time. To bridge this gap, we introduce a new dataset, annotations, and multiple downstream tasks that provide diverse ways to readout information about brain structure and architecture from the same image. Our multi-task neuroimaging benchmark (MTNeuro) is built on volumetric, micrometer-resolution X-ray microtomography images spanning a large thalamocortical section of mouse brain, encompassing multiple cortical and subcortical regions. We generated a number of different prediction challenges and evaluated several supervised and self-supervised models for brain-region prediction and pixel-level semantic segmentation of microstructures. Our experiments not only highlight the rich heterogeneity of this dataset, but also provide insights into how self-supervised approaches can be used to learn representations that capture multiple attributes of a single image and perform well on a variety of downstream tasks. Datasets, code, and pre-trained baseline models are provided at: https://mtneuro.github.io/ .

In this paper, we develop an efficient multi-scale network to predict action classes in partial videos in an end-to-end manner. Unlike most existing methods with offline feature generation, our method directly takes frames as input and further models motion evolution on two different temporal scales.Therefore, we solve the complexity problems of the two stages of modeling and the problem of insufficient temporal and spatial information of a single scale. Our proposed End-to-End MultiScale Network (E2EMSNet) is composed of two scales which are named segment scale and observed global scale. The segment scale leverages temporal difference over consecutive frames for finer motion patterns by supplying 2D convolutions. For observed global scale, a Long Short-Term Memory (LSTM) is incorporated to capture motion features of observed frames. Our model provides a simple and efficient modeling framework with a small computational cost. Our E2EMSNet is evaluated on three challenging datasets: BIT, HMDB51, and UCF101. The extensive experiments demonstrate the effectiveness of our method for action prediction in videos.

Off-policy evaluation (OPE) is a method for estimating the return of a target policy using some pre-collected observational data generated by a potentially different behavior policy. In some cases, there may be unmeasured variables that can confound the action-reward or action-next-state relationships, rendering many existing OPE approaches ineffective. This paper develops an instrumental variable (IV)-based method for consistent OPE in confounded Markov decision processes (MDPs). Similar to single-stage decision making, we show that IV enables us to correctly identify the target policy's value in infinite horizon settings as well. Furthermore, we propose an efficient and robust value estimator and illustrate its effectiveness through extensive simulations and analysis of real data from a world-leading short-video platform.

Patients take care of what their teeth will be like after the orthodontics. Orthodontists usually describe the expectation movement based on the original smile images, which is unconvincing. The growth of deep-learning generative models change this situation. It can visualize the outcome of orthodontic treatment and help patients foresee their future teeth and facial appearance. While previous studies mainly focus on 2D or 3D virtual treatment outcome (VTO) at a profile level, the problem of simulating treatment outcome at a frontal facial image is poorly explored. In this paper, we build an efficient and accurate system for simulating virtual teeth alignment effects in a frontal facial image. Our system takes a frontal face image of a patient with visible malpositioned teeth and the patient's 3D scanned teeth model as input, and progressively generates the visual results of the patient's teeth given the specific orthodontics planning steps from the doctor (i.e., the specification of translations and rotations of individual tooth). We design a multi-modal encoder-decoder based generative model to synthesize identity-preserving frontal facial images with aligned teeth. In addition, the original image color information is used to optimize the orthodontic outcomes, making the results more natural. We conduct extensive qualitative and clinical experiments and also a pilot study to validate our method.

The lack of efficient segmentation methods and fully-labeled datasets limits the comprehensive assessment of optical coherence tomography angiography (OCTA) microstructures like retinal vessel network (RVN) and foveal avascular zone (FAZ), which are of great value in ophthalmic and systematic diseases evaluation. Here, we introduce an innovative OCTA microstructure segmentation network (OMSN) by combining an encoder-decoder-based architecture with multi-scale skip connections and the split-attention-based residual network ResNeSt, paying specific attention to OCTA microstructural features while facilitating better model convergence and feature representations. The proposed OMSN achieves excellent single/multi-task performances for RVN or/and FAZ segmentation. Especially, the evaluation metrics on multi-task models outperform single-task models on the same dataset. On this basis, a fully annotated retinal OCTA segmentation (FAROS) dataset is constructed semi-automatically, filling the vacancy of a pixel-level fully-labeled OCTA dataset. OMSN multi-task segmentation model retrained with FAROS further certifies its outstanding accuracy for simultaneous RVN and FAZ segmentation.