尽管有无数的同伴审查的论文，证明了新颖的人工智能（AI）基于大流行期间的Covid-19挑战的解决方案，但很少有临床影响。人工智能在Covid-19大流行期间的影响因缺乏模型透明度而受到极大的限制。这种系统审查考察了在大流行期间使用可解释的人工智能（Xai）以及如何使用它可以克服现实世界成功的障碍。我们发现，Xai的成功使用可以提高模型性能，灌输信任在最终用户，并提供影响用户决策所需的值。我们将读者介绍给常见的XAI技术，其实用程序以及其应用程序的具体例子。 XAI结果的评估还讨论了最大化AI的临床决策支持系统的价值的重要步骤。我们说明了Xai的古典，现代和潜在的未来趋势，以阐明新颖的XAI技术的演变。最后，我们在最近出版物支持的实验设计过程中提供了建议的清单。潜在解决方案的具体示例也解决了AI解决方案期间的共同挑战。我们希望本次审查可以作为提高未来基于AI的解决方案的临床影响的指导。

The intersection of ground reaction forces in a small, point-like area above the center of mass has been observed in computer simulation models and human walking experiments. This intersection point is often called a virtual pivot point (VPP). With the VPP observed so ubiquitously, it is commonly assumed to provide postural stability for bipedal walking. In this study, we challenge this assumption by questioning if walking without a VPP is possible. Deriving gaits with a neuromuscular reflex model through multi-stage optimization, we found stable walking patterns that show no signs of the VPP-typical intersection of ground reaction forces. We, therefore, conclude that a VPP is not necessary for upright, stable walking. The non-VPP gaits found are stable and successfully rejected step-down perturbations, which indicates that a VPP is not primarily responsible for locomotion robustness or postural stability. However, a collision-based analysis indicates that non-VPP gaits increased the potential for collisions between the vectors of the center of mass velocity and ground reaction forces during walking, suggesting an increased mechanical cost of transport. Although our computer simulation results have yet to be confirmed through experimental studies, they already strongly challenge the existing explanation of the VPP's function and provide an alternative explanation.

In the Earth's magnetosphere, there are fewer than a dozen dedicated probes beyond low-Earth orbit making in-situ observations at any given time. As a result, we poorly understand its global structure and evolution, the mechanisms of its main activity processes, magnetic storms, and substorms. New Artificial Intelligence (AI) methods, including machine learning, data mining, and data assimilation, as well as new AI-enabled missions will need to be developed to meet this Sparse Data challenge.

Dry Eye Disease (DED) is one of the most common ocular diseases: over five percent of US adults suffer from DED. Tear film instability is a known factor for DED, and is thought to be regulated in large part by the thin lipid layer that covers and stabilizes the tear film. In order to aid eye related disease diagnosis, this work proposes a novel paradigm in using computer vision techniques to numerically analyze the tear film lipid layer (TFLL) spread. Eleven videos of the tear film lipid layer spread are collected with a micro-interferometer and a subset are annotated. A tracking algorithm relying on various pillar computer vision techniques is developed. Our method can be found at https://easytear-dev.github.io/.

Automated audio captioning is a cross-modal translation task for describing the content of audio clips with natural language sentences. This task has attracted increasing attention and substantial progress has been made in recent years. Captions generated by existing models are generally faithful to the content of audio clips, however, these machine-generated captions are often deterministic (e.g., generating a fixed caption for a given audio clip), simple (e.g., using common words and simple grammar), and generic (e.g., generating the same caption for similar audio clips). When people are asked to describe the content of an audio clip, different people tend to focus on different sound events and describe an audio clip diversely from various aspects using distinct words and grammar. We believe that an audio captioning system should have the ability to generate diverse captions, either for a fixed audio clip, or across similar audio clips. To this end, we propose an adversarial training framework based on a conditional generative adversarial network (C-GAN) to improve diversity of audio captioning systems. A caption generator and two hybrid discriminators compete and are learned jointly, where the caption generator can be any standard encoder-decoder captioning model used to generate captions, and the hybrid discriminators assess the generated captions from different criteria, such as their naturalness and semantics. We conduct experiments on the Clotho dataset. The results show that our proposed model can generate captions with better diversity as compared to state-of-the-art methods.

Automated software debugging is a crucial task for improving the productivity of software developers. Many neural-based techniques have been proven effective for debugging-related tasks such as bug localization and program repair (or bug fixing). However, these techniques often focus only on either one of them or approach them in a stage-wise manner, ignoring the mutual benefits between them. In this work, we propose a novel unified \emph{Detect-Localize-Repair} framework based on a pretrained programming language model CodeT5 to seamlessly address these tasks, named CodeT5-DLR. Specifically, we propose three objectives to adapt the generic CodeT5 for debugging: a bug detection objective to determine whether a given code snippet is buggy or not, a bug localization objective to identify the buggy lines, and a program repair objective to translate the buggy code to its fixed version. We evaluate it on each of these tasks and their combined setting on two newly collected line-level debugging datasets in Java and Python. Extensive results show that our model significantly outperforms existing baselines from both NLP and software engineering domains.

Artificial Intelligence (AI) is having a tremendous impact across most areas of science. Applications of AI in healthcare have the potential to improve our ability to detect, diagnose, prognose, and intervene on human disease. For AI models to be used clinically, they need to be made safe, reproducible and robust, and the underlying software framework must be aware of the particularities (e.g. geometry, physiology, physics) of medical data being processed. This work introduces MONAI, a freely available, community-supported, and consortium-led PyTorch-based framework for deep learning in healthcare. MONAI extends PyTorch to support medical data, with a particular focus on imaging, and provide purpose-specific AI model architectures, transformations and utilities that streamline the development and deployment of medical AI models. MONAI follows best practices for software-development, providing an easy-to-use, robust, well-documented, and well-tested software framework. MONAI preserves the simple, additive, and compositional approach of its underlying PyTorch libraries. MONAI is being used by and receiving contributions from research, clinical and industrial teams from around the world, who are pursuing applications spanning nearly every aspect of healthcare.

步态冻结（FOG）是帕金森氏病的最常见症状之一，这是中枢神经系统的神经退行性疾病，影响了世界各地数百万的人。为了满足提高雾的治疗质量的紧迫需求，设计雾计算机辅助检测和量化工具的需求越来越重要。作为一种用于收集运动模式的非侵入性技术，从压力敏感步态垫中获得的脚步压力序列为评估诊所和家庭环境中的雾气提供了绝佳的机会。在这项研究中，提出了雾检测为一项顺序建模任务，并提出了一种新颖的深度学习结构，即对对抗性时空网络（ASTN），提出了跨多个级别的雾模式。引入了一种新型的对抗训练方案，并具有多级主题鉴别器，以获得独立的雾代表示，这有助于降低由于高主体间方差而导致的过度拟合风险。结果，对于看不见的受试者，可以实现强大的雾检测。拟议的计划还阐明了从其他场景中改善主题级临床研究，因为它可以与许多现有的深层建筑集成在一起。据我们所知，这是基于脚步压力的雾检测的最早研究之一，利用ASTN的方法是追求独立于主题的表示形式的第一个深神经网络架构。从21名受试者收集的393次试验的实验结果表明，AUC 0.85的雾检测提出的ASTN表现令人鼓舞。

机器学习潜力是分子模拟的重要工具，但是由于缺乏高质量数据集来训练它们的发展，它们的开发阻碍了它们。我们描述了Spice数据集，这是一种新的量子化学数据集，用于训练与模拟与蛋白质相互作用的药物样的小分子相关的潜在。它包含超过110万个小分子，二聚体，二肽和溶剂化氨基酸的构象。它包括15个元素，带电和未充电的分子以及广泛的共价和非共价相互作用。它提供了在{\ omega} b97m-d3（bj）/def2-tzVPPD理论水平以及其他有用的数量（例如多极矩和键阶）上计算出的力和能量。我们在其上训练一组机器学习潜力，并证明它们可以在化学空间的广泛区域中实现化学精度。它可以作为创建可转移的，准备使用潜在功能用于分子模拟的宝贵资源。

噪声的去除或取消对成像和声学具有广泛的应用。在日常生活中，Denoising甚至可能包括对地面真理不忠的生成方面。但是，对于科学应用，denoing必须准确地重现地面真相。在这里，我们展示了如何通过深层卷积神经网络来定位数据，从而以定量精度出现弱信号。特别是，我们研究了晶体材料的X射线衍射。我们证明，弱信号是由电荷排序引起的，在嘈杂的数据中微不足道的信号，在DeNo的数据中变得可见和准确。通过对深度神经网络的监督培训，具有成对的低噪声数据，可以通过监督培训来实现这一成功。这样，神经网络就可以了解噪声的统计特性。我们证明，使用人造噪声（例如泊松和高斯）不会产生这种定量准确的结果。因此，我们的方法说明了一种实用的噪声过滤策略，可以应用于具有挑战性的获取问题。