估算随机实验的因果效应是临床研究的核心。降低这些分析中的统计不确定性是统计学家的重要目标。注册管理机构，事先审判和健康记录构成了对患者的历史数据汇编，其在可能是可利用至此的患者下的历史数据。但是，大多数历史借贷方法通过牺牲严格的I型错误率控制来达到方差的减少。在这里，我们建议使用利用线性协变调整的历史数据来提高试验分析的效率而不会产生偏见。具体而言，我们在历史数据上培训预后模型，然后使用线性回归估计治疗效果，同时调整试验受试者预测结果（其预后分数）。我们证明，在某些条件下，这种预后调整程序在大类估算仪中获得了最低差异。当不符合这些条件时，预后的协变量调整仍然比原始协变量调整更有效，并且效率的增益与上述预后模型的预测准确性的衡量标准成正比，与原始协变量的线性关系的预测准确性。我们展示了使用模拟的方法和阿尔茨海默病的临床试验的再分析，并观察平均平均误差的有意义减少和估计方差。最后，我们提供了一种简化的渐近方差公式，使得能够计算这些收益的功率计算。在使用预后模型的预后模型中，可以实现10％和30％的样品尺寸减少。

This paper expounds the design and control of a new Variable Stiffness Series Elastic Actuator (VSSEA). It is established by employing a modular mechanical design approach that allows us to effectively optimise the stiffness modulation characteristics and power density of the actuator. The proposed VSSEA possesses the following features: i) no limitation in the work-range of output link, ii) a wide range of stiffness modulation (~20Nm/rad to ~1KNm/rad), iii) low-energy-cost stiffness modulation at equilibrium and non-equilibrium positions, iv) compact design and high torque density (~36Nm/kg), and v) high-speed stiffness modulation (~3000Nm/rad/s). Such features can help boost the safety and performance of many advanced robotic systems, e.g., a cobot that physically interacts with unstructured environments and an exoskeleton that provides physical assistance to human users. These features can also enable us to utilise variable stiffness property to attain various regulation and trajectory tracking control tasks only by employing conventional controllers, eliminating the need for synthesising complex motion control systems in compliant actuation. To this end, it is experimentally demonstrated that the proposed VSSEA is capable of precisely tracking desired position and force control references through the use of conventional Proportional-Integral-Derivative (PID) controllers.

We present temporally layered architecture (TLA), a biologically inspired system for temporally adaptive distributed control. TLA layers a fast and a slow controller together to achieve temporal abstraction that allows each layer to focus on a different time-scale. Our design is biologically inspired and draws on the architecture of the human brain which executes actions at different timescales depending on the environment's demands. Such distributed control design is widespread across biological systems because it increases survivability and accuracy in certain and uncertain environments. We demonstrate that TLA can provide many advantages over existing approaches, including persistent exploration, adaptive control, explainable temporal behavior, compute efficiency and distributed control. We present two different algorithms for training TLA: (a) Closed-loop control, where the fast controller is trained over a pre-trained slow controller, allowing better exploration for the fast controller and closed-loop control where the fast controller decides whether to "act-or-not" at each timestep; and (b) Partially open loop control, where the slow controller is trained over a pre-trained fast controller, allowing for open loop-control where the slow controller picks a temporally extended action or defers the next n-actions to the fast controller. We evaluated our method on a suite of continuous control tasks and demonstrate the advantages of TLA over several strong baselines.

Targeted syntactic evaluations of language models ask whether models show stable preferences for syntactically acceptable content over minimal-pair unacceptable inputs. Most targeted syntactic evaluation datasets ask models to make these judgements with just a single context-free sentence as input. This does not match language models' training regime, in which input sentences are always highly contextualized by the surrounding corpus. This mismatch raises an important question: how robust are models' syntactic judgements in different contexts? In this paper, we investigate the stability of language models' performance on targeted syntactic evaluations as we vary properties of the input context: the length of the context, the types of syntactic phenomena it contains, and whether or not there are violations of grammaticality. We find that model judgements are generally robust when placed in randomly sampled linguistic contexts. However, they are substantially unstable for contexts containing syntactic structures matching those in the critical test content. Among all tested models (GPT-2 and five variants of OPT), we significantly improve models' judgements by providing contexts with matching syntactic structures, and conversely significantly worsen them using unacceptable contexts with matching but violated syntactic structures. This effect is amplified by the length of the context, except for unrelated inputs. We show that these changes in model performance are not explainable by simple features matching the context and the test inputs, such as lexical overlap and dependency overlap. This sensitivity to highly specific syntactic features of the context can only be explained by the models' implicit in-context learning abilities.

Neural information retrieval (IR) systems have progressed rapidly in recent years, in large part due to the release of publicly available benchmarking tasks. Unfortunately, some dimensions of this progress are illusory: the majority of the popular IR benchmarks today focus exclusively on downstream task accuracy and thus conceal the costs incurred by systems that trade away efficiency for quality. Latency, hardware cost, and other efficiency considerations are paramount to the deployment of IR systems in user-facing settings. We propose that IR benchmarks structure their evaluation methodology to include not only metrics of accuracy, but also efficiency considerations such as a query latency and the corresponding cost budget for a reproducible hardware setting. For the popular IR benchmarks MS MARCO and XOR-TyDi, we show how the best choice of IR system varies according to how these efficiency considerations are chosen and weighed. We hope that future benchmarks will adopt these guidelines toward more holistic IR evaluation.

White matter bundle segmentation is a cornerstone of modern tractography to study the brain's structural connectivity in domains such as neurological disorders, neurosurgery, and aging. In this study, we present FIESTA (FIber gEneration and bundle Segmentation in Tractography using Autoencoders), a reliable and robust, fully automated, and easily semi-automatically calibrated pipeline based on deep autoencoders that can dissect and fully populate WM bundles. Our framework allows the transition from one anatomical bundle definition to another with marginal calibrating time. This pipeline is built upon FINTA, CINTA, and GESTA methods that demonstrated how autoencoders can be used successfully for streamline filtering, bundling, and streamline generation in tractography. Our proposed method improves bundling coverage by recovering hard-to-track bundles with generative sampling through the latent space seeding of the subject bundle and the atlas bundle. A latent space of streamlines is learned using autoencoder-based modeling combined with contrastive learning. Using an atlas of bundles in standard space (MNI), our proposed method segments new tractograms using the autoencoder latent distance between each tractogram streamline and its closest neighbor bundle in the atlas of bundles. Intra-subject bundle reliability is improved by recovering hard-to-track streamlines, using the autoencoder to generate new streamlines that increase each bundle's spatial coverage while remaining anatomically meaningful. Results show that our method is more reliable than state-of-the-art automated virtual dissection methods such as RecoBundles, RecoBundlesX, TractSeg, White Matter Analysis and XTRACT. Overall, these results show that our framework improves the practicality and usability of current state-of-the-art bundling framework

We present the CUNI-Bergamot submission for the WMT22 General translation task. We compete in English$\rightarrow$Czech direction. Our submission further explores block backtranslation techniques. Compared to the previous work, we measure performance in terms of COMET score and named entities translation accuracy. We evaluate performance of MBR decoding compared to traditional mixed backtranslation training and we show a possible synergy when using both of the techniques simultaneously. The results show that both approaches are effective means of improving translation quality and they yield even better results when combined.

An effective aggregation of node features into a graph-level representation via readout functions is an essential step in numerous learning tasks involving graph neural networks. Typically, readouts are simple and non-adaptive functions designed such that the resulting hypothesis space is permutation invariant. Prior work on deep sets indicates that such readouts might require complex node embeddings that can be difficult to learn via standard neighborhood aggregation schemes. Motivated by this, we investigate the potential of adaptive readouts given by neural networks that do not necessarily give rise to permutation invariant hypothesis spaces. We argue that in some problems such as binding affinity prediction where molecules are typically presented in a canonical form it might be possible to relax the constraints on permutation invariance of the hypothesis space and learn a more effective model of the affinity by employing an adaptive readout function. Our empirical results demonstrate the effectiveness of neural readouts on more than 40 datasets spanning different domains and graph characteristics. Moreover, we observe a consistent improvement over standard readouts (i.e., sum, max, and mean) relative to the number of neighborhood aggregation iterations and different convolutional operators.

Despite the rapid progress of open-domain generation-based conversational agents, most deployed systems treat dialogue contexts as single-turns, while systems dealing with multi-turn contexts are less studied. There is a lack of a reliable metric for evaluating multi-turn modelling, as well as an effective solution for improving it. In this paper, we focus on an essential component of multi-turn generation-based conversational agents: context attention distribution, i.e. how systems distribute their attention on dialogue's context. For evaluation of this component, We introduce a novel attention-mechanism-based metric: DAS ratio. To improve performance on this component, we propose an optimization strategy that employs self-contained distractions. Our experiments on the Ubuntu chatlogs dataset show that models with comparable perplexity can be distinguished by their ability on context attention distribution. Our proposed optimization strategy improves both non-hierarchical and hierarchical models on the proposed metric by about 10% from baselines.

数据质量是发展医疗保健中值得信赖的AI的关键因素。大量具有控制混杂因素的策划数据集可以帮助提高下游AI算法的准确性，鲁棒性和隐私性。但是，访问高质量的数据集受数据获取的技术难度的限制，并且严格的道德限制阻碍了医疗保健数据的大规模共享。数据合成算法生成具有与真实临床数据相似的分布的数据，可以作为解决可信度AI的发展过程中缺乏优质数据的潜在解决方案。然而，最新的数据合成算法，尤其是深度学习算法，更多地集中于成像数据，同时忽略了非成像医疗保健数据的综合，包括临床测量，医疗信号和波形以及电子保健记录（EHRS）（EHRS） 。因此，在本文中，我们将回顾合成算法，尤其是对于非成像医学数据，目的是在该领域提供可信赖的AI。本教程风格的审查论文将对包括算法，评估，局限性和未来研究方向在内的各个方面进行全面描述。