The viral load of patients infected with SARS-CoV-2 varies on logarithmic scales and possibly with age. Controversial claims have been made in the literature regarding whether the viral load distribution actually depends on the age of the patients. Such a dependence would have implications for the COVID-19 spreading mechanism, the age-dependent immune system reaction, and thus for policymaking. We hereby develop a method to analyze viral-load distribution data as a function of the patients' age within a flexible, non-parametric, hierarchical, Bayesian, and causal model. The causal nature of the developed reconstruction additionally allows to test for bias in the data. This could be due to, e.g., bias in patient-testing and data collection or systematic errors in the measurement of the viral load. We perform these tests by calculating the Bayesian evidence for each implied possible causal direction. The possibility of testing for bias in data collection and identifying causal directions can be very useful in other contexts as well. For this reason we make our model freely available. When applied to publicly available age and SARS-CoV-2 viral load data, we find a statistically significant increase in the viral load with age, but only for one of the two analyzed datasets. If we consider this dataset, and based on the current understanding of viral load's impact on patients' infectivity, we expect a non-negligible difference in the infectivity of different age groups. This difference is nonetheless too small to justify considering any age group as noninfectious.

Despite the success of large language models (LLMs) in various natural language processing (NLP) tasks, the stored knowledge in these models may inevitably be incomplete, out-of-date, or incorrect. This motivates the need to utilize external knowledge to assist LLMs. Unfortunately, current methods for incorporating external knowledge often require additional training or fine-tuning, which can be costly and may not be feasible for LLMs. To address this issue, we propose a novel post-processing approach, rethinking with retrieval (RR), which retrieves relevant external knowledge based on the decomposed reasoning steps obtained from the chain-of-thought (CoT) prompting. This lightweight approach does not require additional training or fine-tuning and is not limited by the input length of LLMs. We evaluate the effectiveness of RR through extensive experiments with GPT-3 on three complex reasoning tasks: commonsense reasoning, temporal reasoning, and tabular reasoning. Our results show that RR can produce more faithful explanations and improve the performance of LLMs.

The release of ChatGPT, a language model capable of generating text that appears human-like and authentic, has gained significant attention beyond the research community. We expect that the convincing performance of ChatGPT incentivizes users to apply it to a variety of downstream tasks, including prompting the model to simplify their own medical reports. To investigate this phenomenon, we conducted an exploratory case study. In a questionnaire, we asked 15 radiologists to assess the quality of radiology reports simplified by ChatGPT. Most radiologists agreed that the simplified reports were factually correct, complete, and not potentially harmful to the patient. Nevertheless, instances of incorrect statements, missed key medical findings, and potentially harmful passages were reported. While further studies are needed, the initial insights of this study indicate a great potential in using large language models like ChatGPT to improve patient-centered care in radiology and other medical domains.

Magnetic Resonance Fingerprinting (MRF) is an efficient quantitative MRI technique that can extract important tissue and system parameters such as T1, T2, B0, and B1 from a single scan. This property also makes it attractive for retrospectively synthesizing contrast-weighted images. In general, contrast-weighted images like T1-weighted, T2-weighted, etc., can be synthesized directly from parameter maps through spin-dynamics simulation (i.e., Bloch or Extended Phase Graph models). However, these approaches often exhibit artifacts due to imperfections in the mapping, the sequence modeling, and the data acquisition. Here we propose a supervised learning-based method that directly synthesizes contrast-weighted images from the MRF data without going through the quantitative mapping and spin-dynamics simulation. To implement our direct contrast synthesis (DCS) method, we deploy a conditional Generative Adversarial Network (GAN) framework and propose a multi-branch U-Net as the generator. The input MRF data are used to directly synthesize T1-weighted, T2-weighted, and fluid-attenuated inversion recovery (FLAIR) images through supervised training on paired MRF and target spin echo-based contrast-weighted scans. In-vivo experiments demonstrate excellent image quality compared to simulation-based contrast synthesis and previous DCS methods, both visually as well as by quantitative metrics. We also demonstrate cases where our trained model is able to mitigate in-flow and spiral off-resonance artifacts that are typically seen in MRF reconstructions and thus more faithfully represent conventional spin echo-based contrast-weighted images.

The widely studied task of Natural Language Inference (NLI) requires a system to recognize whether one piece of text is textually entailed by another, i.e. whether the entirety of its meaning can be inferred from the other. In current NLI datasets and models, textual entailment relations are typically defined on the sentence- or paragraph-level. However, even a simple sentence often contains multiple propositions, i.e. distinct units of meaning conveyed by the sentence. As these propositions can carry different truth values in the context of a given premise, we argue for the need to recognize the textual entailment relation of each proposition in a sentence individually. We propose PropSegmEnt, a corpus of over 35K propositions annotated by expert human raters. Our dataset structure resembles the tasks of (1) segmenting sentences within a document to the set of propositions, and (2) classifying the entailment relation of each proposition with respect to a different yet topically-aligned document, i.e. documents describing the same event or entity. We establish strong baselines for the segmentation and entailment tasks. Through case studies on summary hallucination detection and document-level NLI, we demonstrate that our conceptual framework is potentially useful for understanding and explaining the compositionality of NLI labels.

Temporal reasoning is the task of predicting temporal relations of event pairs with corresponding contexts. While some temporal reasoning models perform reasonably well on in-domain benchmarks, we have little idea of the systems' generalizability due to existing datasets' limitations. In this work, we introduce a novel task named TODAY that bridges this gap with temporal differential analysis, which as the name suggests, evaluates if systems can correctly understand the effect of incremental changes. Specifically, TODAY makes slight context changes for given event pairs, and systems need to tell how this subtle contextual change will affect temporal relation distributions. To facilitate learning, TODAY also annotates human explanations. We show that existing models, including GPT-3, drop to random guessing on TODAY, suggesting that they heavily rely on spurious information rather than proper reasoning for temporal predictions. On the other hand, we show that TODAY's supervision style and explanation annotations can be used in joint learning and encourage models to use more appropriate signals during training and outperform across several benchmarks. TODAY can also be used to train models to solicit incidental supervision from noisy sources such as GPT-3 and moves farther towards generic temporal reasoning systems.

Estimating the 6D pose of objects is one of the major fields in 3D computer vision. Since the promising outcomes from instance-level pose estimation, the research trends are heading towards category-level pose estimation for more practical application scenarios. However, unlike well-established instance-level pose datasets, available category-level datasets lack annotation quality and provided pose quantity. We propose the new category level 6D pose dataset HouseCat6D featuring 1) Multi-modality of Polarimetric RGB+P and Depth, 2) Highly diverse 194 objects of 10 household object categories including 2 photometrically challenging categories, 3) High-quality pose annotation with an error range of only 1.35 mm to 1.74 mm, 4) 41 large scale scenes with extensive viewpoint coverage, 5) Checkerboard-free environment throughout the entire scene. We also provide benchmark results of state-of-the-art category-level pose estimation networks.

Code generation models have achieved impressive performance. However, they tend to be brittle as slight edits to a prompt could lead to very different generations; these robustness properties, critical for user experience when deployed in real-life applications, are not well understood. Most existing works on robustness in text or code tasks have focused on classification, while robustness in generation tasks is an uncharted area and to date there is no comprehensive benchmark for robustness in code generation. In this paper, we propose ReCode, a comprehensive robustness evaluation benchmark for code generation models. We customize over 30 transformations specifically for code on docstrings, function and variable names, code syntax, and code format. They are carefully designed to be natural in real-life coding practice, preserve the original semantic meaning, and thus provide multifaceted assessments of a model's robustness performance. With human annotators, we verified that over 90% of the perturbed prompts do not alter the semantic meaning of the original prompt. In addition, we define robustness metrics for code generation models considering the worst-case behavior under each type of perturbation, taking advantage of the fact that executing the generated code can serve as objective evaluation. We demonstrate ReCode on SOTA models using HumanEval, MBPP, as well as function completion tasks derived from them. Interesting observations include: better robustness for CodeGen over InCoder and GPT-J; models are most sensitive to syntax perturbations; more challenging robustness evaluation on MBPP over HumanEval.

Recently it has been shown that state-of-the-art NLP models are vulnerable to adversarial attacks, where the predictions of a model can be drastically altered by slight modifications to the input (such as synonym substitutions). While several defense techniques have been proposed, and adapted, to the discrete nature of text adversarial attacks, the benefits of general-purpose regularization methods such as label smoothing for language models, have not been studied. In this paper, we study the adversarial robustness provided by various label smoothing strategies in foundational models for diverse NLP tasks in both in-domain and out-of-domain settings. Our experiments show that label smoothing significantly improves adversarial robustness in pre-trained models like BERT, against various popular attacks. We also analyze the relationship between prediction confidence and robustness, showing that label smoothing reduces over-confident errors on adversarial examples.

While pre-trained language models (LM) for code have achieved great success in code completion, they generate code conditioned only on the contents within the file, i.e., in-file context, but ignore the rich semantics in other files within the same project, i.e., cross-file context, a critical source of information that is especially useful in modern modular software development. Such overlooking constrains code language models' capacity in code completion, leading to unexpected behaviors such as generating hallucinated class member functions or function calls with unexpected arguments. In this work, we develop a cross-file context finder tool, CCFINDER, that effectively locates and retrieves the most relevant cross-file context. We propose CoCoMIC, a framework that incorporates cross-file context to learn the in-file and cross-file context jointly on top of pretrained code LMs. CoCoMIC successfully improves the existing code LM with a 19.30% relative increase in exact match and a 15.41% relative increase in identifier matching for code completion when the cross-file context is provided.