疾病鉴定是观察健康研究中的核心，常规活动。队列影响下游分析，例如如何表征病情，定义患者的风险以及研究哪些治疗方法。因此，至关重要的是要确保选定的队列代表所有患者，而与他们的人口统计学或社会决定因素无关。虽然在构建可能影响其公平性的表型定义时有多种潜在的偏见来源，但在表型领域中考虑不同定义在患者亚组中的影响并不是标准。在本文中，我们提出了一组最佳实践来评估表型定义的公平性。我们利用预测模型中常用的既定公平指标，并将其与常用的流行病学队列描述指标联系起来。我们描述了一项针对克罗恩病和2型糖尿病的实证研究，每个研究都有从两组患者亚组（性别和种族）中从文献中获取的多种表型定义。我们表明，根据不同的公平指标和亚组，不同的表型定义表现出较大和不同的性能。我们希望拟议的最佳实践可以帮助构建公平和包容的表型定义。

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

As a novel distributed learning paradigm, federated learning (FL) faces serious challenges in dealing with massive clients with heterogeneous data distribution and computation and communication resources. Various client-variance-reduction schemes and client sampling strategies have been respectively introduced to improve the robustness of FL. Among others, primal-dual algorithms such as the alternating direction of method multipliers (ADMM) have been found being resilient to data distribution and outperform most of the primal-only FL algorithms. However, the reason behind remains a mystery still. In this paper, we firstly reveal the fact that the federated ADMM is essentially a client-variance-reduced algorithm. While this explains the inherent robustness of federated ADMM, the vanilla version of it lacks the ability to be adaptive to the degree of client heterogeneity. Besides, the global model at the server under client sampling is biased which slows down the practical convergence. To go beyond ADMM, we propose a novel primal-dual FL algorithm, termed FedVRA, that allows one to adaptively control the variance-reduction level and biasness of the global model. In addition, FedVRA unifies several representative FL algorithms in the sense that they are either special instances of FedVRA or are close to it. Extensions of FedVRA to semi/un-supervised learning are also presented. Experiments based on (semi-)supervised image classification tasks demonstrate superiority of FedVRA over the existing schemes in learning scenarios with massive heterogeneous clients and client sampling.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

本文分析了交付功能步态结果的联合空间步行机制和冗余。分析了两名参加多因素研究并在三个课程中行走的健康男性成年人的生物力学措施。两位参与者都采用不同的人体内部和人际补偿策略（例如，拱顶，髋关节远足）跨步行条件，并表现出显着的步态模式改变，同时保持任务空间（功能）步态参数不变。他们还更喜欢各种不对称的步长，但在自由步行过程中保持了对称步长的一致性和Cadence-Invariant。结果表明，个性化方法的重要性以及需要从功能（任务空间）到关节空间步态分析的范式转变，以便在（a）典型步态和提供以人为中心的人类机器人相互作用。

数据增强是自然语言处理（NLP）模型的鲁棒性评估的重要组成部分，以及增强他们培训的数据的多样性。在本文中，我们呈现NL-Cogmenter，这是一种新的参与式Python的自然语言增强框架，它支持创建两个转换（对数据的修改）和过滤器（根据特定功能的数据拆分）。我们描述了框架和初始的117个变换和23个过滤器，用于各种自然语言任务。我们通过使用其几个转换来分析流行自然语言模型的鲁棒性来证明NL-Upmenter的功效。基础架构，Datacards和稳健性分析结果在NL-Augmenter存储库上公开可用（\ url {https://github.com/gem-benchmark/nl-augmenter}）。

We present Second Thought, a new learning paradigm that enables language models (LMs) to re-align with human values. By modeling the chain-of-edits between value-unaligned and value-aligned text, with LM fine-tuning and additional refinement through reinforcement learning, Second Thought not only achieves superior performance in three value alignment benchmark datasets but also shows strong human-value transfer learning ability in few-shot scenarios. The generated editing steps also offer better interpretability and ease for interactive error correction. Extensive human evaluations further confirm its effectiveness.

As various city agencies and mobility operators navigate toward innovative mobility solutions, there is a need for strategic flexibility in well-timed investment decisions in the design and timing of mobility service regions, i.e. cast as "real options" (RO). This problem becomes increasingly challenging with multiple interacting RO in such investments. We propose a scalable machine learning based RO framework for multi-period sequential service region design & timing problem for mobility-on-demand services, framed as a Markov decision process with non-stationary stochastic variables. A value function approximation policy from literature uses multi-option least squares Monte Carlo simulation to get a policy value for a set of interdependent investment decisions as deferral options (CR policy). The goal is to determine the optimal selection and timing of a set of zones to include in a service region. However, prior work required explicit enumeration of all possible sequences of investments. To address the combinatorial complexity of such enumeration, we propose a new variant "deep" RO policy using an efficient recurrent neural network (RNN) based ML method (CR-RNN policy) to sample sequences to forego the need for enumeration, making network design & timing policy tractable for large scale implementation. Experiments on multiple service region scenarios in New York City (NYC) shows the proposed policy substantially reduces the overall computational cost (time reduction for RO evaluation of > 90% of total investment sequences is achieved), with zero to near-zero gap compared to the benchmark. A case study of sequential service region design for expansion of MoD services in Brooklyn, NYC show that using the CR-RNN policy to determine optimal RO investment strategy yields a similar performance (0.5% within CR policy value) with significantly reduced computation time (about 5.4 times faster).

The ability to distinguish between different movie scenes is critical for understanding the storyline of a movie. However, accurately detecting movie scenes is often challenging as it requires the ability to reason over very long movie segments. This is in contrast to most existing video recognition models, which are typically designed for short-range video analysis. This work proposes a State-Space Transformer model that can efficiently capture dependencies in long movie videos for accurate movie scene detection. Our model, dubbed TranS4mer, is built using a novel S4A building block, which combines the strengths of structured state-space sequence (S4) and self-attention (A) layers. Given a sequence of frames divided into movie shots (uninterrupted periods where the camera position does not change), the S4A block first applies self-attention to capture short-range intra-shot dependencies. Afterward, the state-space operation in the S4A block is used to aggregate long-range inter-shot cues. The final TranS4mer model, which can be trained end-to-end, is obtained by stacking the S4A blocks one after the other multiple times. Our proposed TranS4mer outperforms all prior methods in three movie scene detection datasets, including MovieNet, BBC, and OVSD, while also being $2\times$ faster and requiring $3\times$ less GPU memory than standard Transformer models. We will release our code and models.

Springs are efficient in storing and returning elastic potential energy but are unable to hold the energy they store in the absence of an external load. Lockable springs use clutches to hold elastic potential energy in the absence of an external load but have not yet been widely adopted in applications, partly because clutches introduce design complexity, reduce energy efficiency, and typically do not afford high-fidelity control over the energy stored by the spring. Here, we present the design of a novel lockable compression spring that uses a small capstan clutch to passively lock a mechanical spring. The capstan clutch can lock up to 1000 N force at any arbitrary deflection, unlock the spring in less than 10 ms with a control force less than 1 % of the maximal spring force, and provide an 80 % energy storage and return efficiency (comparable to a highly efficient electric motor operated at constant nominal speed). By retaining the form factor of a regular spring while providing high-fidelity locking capability even under large spring forces, the proposed design could facilitate the development of energy-efficient spring-based actuators and robots.