Vehicle routing problems and other combinatorial optimization problems have been approximately solved by reinforcement learning agents with policies based on encoder-decoder models with attention mechanisms. These techniques are of substantial interest but still cannot solve the complex routing problems that arise in a realistic setting which can have many trucks and complex requirements. With the aim of making reinforcement learning a viable technique for supply chain optimization, we develop new extensions to encoder-decoder models for vehicle routing that allow for complex supply chains using classical computing today and quantum computing in the future. We make two major generalizations. First, our model allows for routing problems with multiple trucks. Second, we move away from the simple requirement of having a truck deliver items from nodes to one special depot node, and instead allow for a complex tensor demand structure. We show how our model, even if trained only for a small number of trucks, can be embedded into a large supply chain to yield viable solutions.

Problem instances of a size suitable for practical applications are not likely to be addressed during the noisy intermediate-scale quantum (NISQ) period with (almost) pure quantum algorithms. Hybrid classical-quantum algorithms have potential, however, to achieve good performance on much larger problem instances. We investigate one such hybrid algorithm on a problem of substantial importance: vehicle routing for supply chain logistics with multiple trucks and complex demand structure. We use reinforcement learning with neural networks with embedded quantum circuits. In such neural networks, projecting high-dimensional feature vectors down to smaller vectors is necessary to accommodate restrictions on the number of qubits of NISQ hardware. However, we use a multi-head attention mechanism where, even in classical machine learning, such projections are natural and desirable. We consider data from the truck routing logistics of a company in the automotive sector, and apply our methodology by decomposing into small teams of trucks, and we find results comparable to human truck assignment.

While the capabilities of autonomous systems have been steadily improving in recent years, these systems still struggle to rapidly explore previously unknown environments without the aid of GPS-assisted navigation. The DARPA Subterranean (SubT) Challenge aimed to fast track the development of autonomous exploration systems by evaluating their performance in real-world underground search-and-rescue scenarios. Subterranean environments present a plethora of challenges for robotic systems, such as limited communications, complex topology, visually-degraded sensing, and harsh terrain. The presented solution enables long-term autonomy with minimal human supervision by combining a powerful and independent single-agent autonomy stack, with higher level mission management operating over a flexible mesh network. The autonomy suite deployed on quadruped and wheeled robots was fully independent, freeing the human supervision to loosely supervise the mission and make high-impact strategic decisions. We also discuss lessons learned from fielding our system at the SubT Final Event, relating to vehicle versatility, system adaptability, and re-configurable communications.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

血氧水平依赖性（BOLD）用母体高氧可以评估胎盘内的氧运输，并已成为研究胎盘功能的有前途的工具。测量信号随着时间的变化需要在时间序列的每个体积中分割胎盘。由于大胆的时间序列中的数量大量，现有研究依靠注册将所有卷映射到手动分段模板。由于胎盘由于胎儿运动，母体运动和收缩而导致大变形，因此这种方法通常会导致大量废弃体积，而注册方法失败。在这项工作中，我们提出了一个基于U-NET神经网络体系结构的机器学习模型，以自动以粗体MRI分割胎盘，并将其应用于时间序列中的每个卷。我们使用边界加权损失函数来准确捕获胎盘形状。我们的模型经过训练和测试，并在91位包含健康胎儿的受试者，胎儿生长限制的胎儿以及BMI高的母亲中进行了测试。当与地面真实标签匹配时，我们的骰子得分为0.83 +/- 0.04，并且我们的模型在粗体时间序列中可靠地分割量氧和高氧点的量。我们的代码和训练有素的模型可在https://github.com/mabulnaga/automatic-placenta-mentegation上获得。

语言模型既展示了定量的改进，又展示了新的定性功能，随着规模的增加。尽管它们具有潜在的变革性影响，但这些新能力的特征却很差。为了为未来的研究提供信息，为破坏性的新模型能力做准备，并改善社会有害的效果，至关重要的是，我们必须了解目前和近乎未来的能力和语言模型的局限性。为了应对这一挑战，我们介绍了超越模仿游戏基准（Big Bench）。 Big Bench目前由204个任务组成，由132家机构的442位作者贡献。任务主题是多样的，从语言学，儿童发展，数学，常识性推理，生物学，物理学，社会偏见，软件开发等等。 Big-Bench专注于被认为超出当前语言模型的功能的任务。我们评估了OpenAI的GPT型号，Google内部密集变压器体系结构和大型基础上的开关稀疏变压器的行为，跨越了数百万到数十亿个参数。此外，一个人类专家评估者团队执行了所有任务，以提供强大的基准。研究结果包括：模型性能和校准都随规模改善，但绝对的术语（以及与评估者的性能相比）；在模型类中的性能非常相似，尽管带有稀疏性。逐渐和预测的任务通常涉及大量知识或记忆成分，而在临界规模上表现出“突破性”行为的任务通常涉及多个步骤或组成部分或脆性指标；社交偏见通常会随着含糊不清的环境而随着规模而增加，但这可以通过提示来改善。

Deep learning (DL) is gaining popularity as a parameter estimation method for quantitative MRI. A range of competing implementations have been proposed, relying on either supervised or self-supervised learning. Self-supervised approaches, sometimes referred to as unsupervised, have been loosely based on auto-encoders, whereas supervised methods have, to date, been trained on groundtruth labels. These two learning paradigms have been shown to have distinct strengths. Notably, self-supervised approaches have offered lower-bias parameter estimates than their supervised alternatives. This result is counterintuitive - incorporating prior knowledge with supervised labels should, in theory, lead to improved accuracy. In this work, we show that this apparent limitation of supervised approaches stems from the naive choice of groundtruth training labels. By training on labels which are deliberately not groundtruth, we show that the low-bias parameter estimation previously associated with self-supervised methods can be replicated - and improved on - within a supervised learning framework. This approach sets the stage for a single, unifying, deep learning parameter estimation framework, based on supervised learning, where trade-offs between bias and variance are made by careful adjustment of training label.

Recently developed methods for video analysis, especially models for pose estimation and behavior classification, are transforming behavioral quantification to be more precise, scalable, and reproducible in fields such as neuroscience and ethology. These tools overcome long-standing limitations of manual scoring of video frames and traditional "center of mass" tracking algorithms to enable video analysis at scale. The expansion of open-source tools for video acquisition and analysis has led to new experimental approaches to understand behavior. Here, we review currently available open-source tools for video analysis and discuss how to set up these methods for labs new to video recording. We also discuss best practices for developing and using video analysis methods, including community-wide standards and critical needs for the open sharing of datasets and code, more widespread comparisons of video analysis methods, and better documentation for these methods especially for new users. We encourage broader adoption and continued development of these tools, which have tremendous potential for accelerating scientific progress in understanding the brain and behavior.

我们展示了深度学习模型，特别是像自然语言的变压器那样的架构，可以在随机生成的数据集上培训，以预测代谢网络的定性和定量特征非常高的准确性。使用标准数学技术，我们创建了可以用于训练我们的模型的大型随机网络的大集（40 00万个元素）。这些训练有素的模型可以在超过99％的情况下预测随机图的网络均衡。它们还可以概括与不同结构的图表，而不是在训练时遇到的图表。最后，他们可以预测一小组已知的生物网络的均衡。我们的方法在实验数据中非常经济，并且仅使用小而浅的深度学习模型，远离机器翻译中常用的大型架构。这种结果为更大利用深入学习模型的方法铺平了与定量系统药理学，系统生物学和合成生物学等重点领域相关的问题。

我们为高分辨率自由呼吸肺MRI介绍了无监督的运动补偿重建方案。我们将时间序列中的图像帧模拟为3D模板图像卷的变形版本。我们假设变形图在高维空间中的光滑歧管上是点。具体地，我们在每次时刻模拟变形图作为基于CNN的发电机的输出，该发电机的输出具有由低维潜航向量驱动的所有时间框架的权重。潜伏向量的时间序列占数据集中的动态，包括呼吸运动和散装运动。模板图像卷，发电机的参数，以及潜在矢量的直接从k-t空间数据以无监督的方式学习。我们的实验结果表明，与最先进的方法相比，改进了重建，特别是在扫描期间散装运动的背景下。