加速生物序列设计的能力可以对医疗领域的进度产生重大影响。该问题可以作为一个全球优化问题，在该问题中，该目标是昂贵的黑盒功能，因此我们可以查询大量限制，并限制较少的回合。贝叶斯优化是解决此问题的原则方法。然而，生物序列的天文范围较大的状态空间使所有可能的序列都在不可行。在本文中，我们提出了Metarlbo，在其中我们通过元强化学习训练自回归的生成模型，以提出有希望的序列，以通过贝叶斯优化选择。我们提出了这个问题，因为它是在上一轮中获取的数据的采样子集引起的MDP分布上找到最佳策略的问题。我们的内部实验表明，与现有强大基准相比，对此类合奏的元学习提供了鲁棒性，可抵抗奖励错误指定和实现竞争成果。

我们解决了选择性分类的问题，目标是在数据集的所需覆盖范围内实现最佳性能。最新的最新选择性方法通过引入单独的选择头或额外的弃权logit进行体系结构变化。在本文中，我们通过确认最先进的方法的出色性能归功于培训更具概括的分类器，为选择性分类提供了令人惊讶的结果。但是，他们的选择机制是次优的。我们认为，选择机制应植根于目标函数，而不是单独计算的分数。因此，在本文中，我们激发了一种基于分类设置的横向熵损失的替代选择策略，即logits的最大值。我们提出的选择策略在所有覆盖范围和所有数据集中都可以通过大幅度的边距获得更好的结果，而无需任何其他计算。最后，受到我们优越的选择机制的启发，我们建议通过熵最小化进一步正规化目标函数。我们提出的具有修改后损耗功能的最大选择选择可实现选择性分类的新最新结果。

Increasing research interests focus on sequential recommender systems, aiming to model dynamic sequence representation precisely. However, the most commonly used loss function in state-of-the-art sequential recommendation models has essential limitations. To name a few, Bayesian Personalized Ranking (BPR) loss suffers the vanishing gradient problem from numerous negative sampling and predictionbiases; Binary Cross-Entropy (BCE) loss subjects to negative sampling numbers, thereby it is likely to ignore valuable negative examples and reduce the training efficiency; Cross-Entropy (CE) loss only focuses on the last timestamp of the training sequence, which causes low utilization of sequence information and results in inferior user sequence representation. To avoid these limitations, in this paper, we propose to calculate Cumulative Cross-Entropy (CCE) loss over the sequence. CCE is simple and direct, which enjoys the virtues of painless deployment, no negative sampling, and effective and efficient training. We conduct extensive experiments on five benchmark datasets to demonstrate the effectiveness and efficiency of CCE. The results show that employing CCE loss on three state-of-the-art models GRU4Rec, SASRec, and S3-Rec can reach 125.63%, 69.90%, and 33.24% average improvement of full ranking NDCG@5, respectively. Using CCE, the performance curve of the models on the test data increases rapidly with the wall clock time, and is superior to that of other loss functions in almost the whole process of model training.

In the scenario of black-box adversarial attack, the target model's parameters are unknown, and the attacker aims to find a successful adversarial perturbation based on query feedback under a query budget. Due to the limited feedback information, existing query-based black-box attack methods often require many queries for attacking each benign example. To reduce query cost, we propose to utilize the feedback information across historical attacks, dubbed example-level adversarial transferability. Specifically, by treating the attack on each benign example as one task, we develop a meta-learning framework by training a meta-generator to produce perturbations conditioned on benign examples. When attacking a new benign example, the meta generator can be quickly fine-tuned based on the feedback information of the new task as well as a few historical attacks to produce effective perturbations. Moreover, since the meta-train procedure consumes many queries to learn a generalizable generator, we utilize model-level adversarial transferability to train the meta-generator on a white-box surrogate model, then transfer it to help the attack against the target model. The proposed framework with the two types of adversarial transferability can be naturally combined with any off-the-shelf query-based attack methods to boost their performance, which is verified by extensive experiments.

Supervised Deep-Learning (DL)-based reconstruction algorithms have shown state-of-the-art results for highly-undersampled dynamic Magnetic Resonance Imaging (MRI) reconstruction. However, the requirement of excessive high-quality ground-truth data hinders their applications due to the generalization problem. Recently, Implicit Neural Representation (INR) has appeared as a powerful DL-based tool for solving the inverse problem by characterizing the attributes of a signal as a continuous function of corresponding coordinates in an unsupervised manner. In this work, we proposed an INR-based method to improve dynamic MRI reconstruction from highly undersampled k-space data, which only takes spatiotemporal coordinates as inputs. Specifically, the proposed INR represents the dynamic MRI images as an implicit function and encodes them into neural networks. The weights of the network are learned from sparsely-acquired (k, t)-space data itself only, without external training datasets or prior images. Benefiting from the strong implicit continuity regularization of INR together with explicit regularization for low-rankness and sparsity, our proposed method outperforms the compared scan-specific methods at various acceleration factors. E.g., experiments on retrospective cardiac cine datasets show an improvement of 5.5 ~ 7.1 dB in PSNR for extremely high accelerations (up to 41.6-fold). The high-quality and inner continuity of the images provided by INR has great potential to further improve the spatiotemporal resolution of dynamic MRI, without the need of any training data.

Recent studies have shown that using an external Language Model (LM) benefits the end-to-end Automatic Speech Recognition (ASR). However, predicting tokens that appear less frequently in the training set is still quite challenging. The long-tail prediction problems have been widely studied in many applications, but only been addressed by a few studies for ASR and LMs. In this paper, we propose a new memory augmented lookup dictionary based Transformer architecture for LM. The newly introduced lookup dictionary incorporates rich contextual information in training set, which is vital to correctly predict long-tail tokens. With intensive experiments on Chinese and English data sets, our proposed method is proved to outperform the baseline Transformer LM by a great margin on both word/character error rate and tail tokens error rate. This is achieved without impact on the decoding efficiency. Overall, we demonstrate the effectiveness of our proposed method in boosting the ASR decoding performance, especially for long-tail tokens.

The objective of this paper is to learn dense 3D shape correspondence for topology-varying generic objects in an unsupervised manner. Conventional implicit functions estimate the occupancy of a 3D point given a shape latent code. Instead, our novel implicit function produces a probabilistic embedding to represent each 3D point in a part embedding space. Assuming the corresponding points are similar in the embedding space, we implement dense correspondence through an inverse function mapping from the part embedding vector to a corresponded 3D point. Both functions are jointly learned with several effective and uncertainty-aware loss functions to realize our assumption, together with the encoder generating the shape latent code. During inference, if a user selects an arbitrary point on the source shape, our algorithm can automatically generate a confidence score indicating whether there is a correspondence on the target shape, as well as the corresponding semantic point if there is one. Such a mechanism inherently benefits man-made objects with different part constitutions. The effectiveness of our approach is demonstrated through unsupervised 3D semantic correspondence and shape segmentation.

Patients take care of what their teeth will be like after the orthodontics. Orthodontists usually describe the expectation movement based on the original smile images, which is unconvincing. The growth of deep-learning generative models change this situation. It can visualize the outcome of orthodontic treatment and help patients foresee their future teeth and facial appearance. While previous studies mainly focus on 2D or 3D virtual treatment outcome (VTO) at a profile level, the problem of simulating treatment outcome at a frontal facial image is poorly explored. In this paper, we build an efficient and accurate system for simulating virtual teeth alignment effects in a frontal facial image. Our system takes a frontal face image of a patient with visible malpositioned teeth and the patient's 3D scanned teeth model as input, and progressively generates the visual results of the patient's teeth given the specific orthodontics planning steps from the doctor (i.e., the specification of translations and rotations of individual tooth). We design a multi-modal encoder-decoder based generative model to synthesize identity-preserving frontal facial images with aligned teeth. In addition, the original image color information is used to optimize the orthodontic outcomes, making the results more natural. We conduct extensive qualitative and clinical experiments and also a pilot study to validate our method.

In this paper we take the first steps in studying a new approach to synthesis of efficient communication schemes in multi-agent systems, trained via reinforcement learning. We combine symbolic methods with machine learning, in what is referred to as a neuro-symbolic system. The agents are not restricted to only use initial primitives: reinforcement learning is interleaved with steps to extend the current language with novel higher-level concepts, allowing generalisation and more informative communication via shorter messages. We demonstrate that this approach allow agents to converge more quickly on a small collaborative construction task.

In this paper, we study the \underline{R}obust \underline{o}ptimization for \underline{se}quence \underline{Net}worked \underline{s}ubmodular maximization (RoseNets) problem. We interweave the robust optimization with the sequence networked submodular maximization. The elements are connected by a directed acyclic graph and the objective function is not submodular on the elements but on the edges in the graph. Under such networked submodular scenario, the impact of removing an element from a sequence depends both on its position in the sequence and in the network. This makes the existing robust algorithms inapplicable. In this paper, we take the first step to study the RoseNets problem. We design a robust greedy algorithm, which is robust against the removal of an arbitrary subset of the selected elements. The approximation ratio of the algorithm depends both on the number of the removed elements and the network topology. We further conduct experiments on real applications of recommendation and link prediction. The experimental results demonstrate the effectiveness of the proposed algorithm.