本文开发了一个贝叶斯图形模型，用于融合不同类型的计数数据。激励的应用是从不同治疗方法收集的各种高维特征的细菌群落研究。在这样的数据集中，社区之间没有明确的对应关系，每个对应都与不同的因素相对应，从而使数据融合具有挑战性。我们引入了一种灵活的多项式高斯生成模型，用于共同建模此类计数数据。该潜在变量模型通过共同的多元高斯潜在空间共同表征了观察到的数据，该空间参数化了转录组计数的多项式概率集。潜在变量的协方差矩阵诱导所有转录本之间共同依赖性的协方差矩阵，有效地融合了多个数据源。我们提出了一种可扩展的可扩展性变异期望最大化（EM）算法，用于推断模型的潜在变量和参数。推断的潜在变量为可视化数据提供了常见的维度降低，而推断的参数则提供了预测性的后验分布。除了证明变异性程序的模拟研究外，我们还将模型应用于细菌微生物组数据集。

匪徒问题的最新作品在顺序决策环境中采用了拉索融合理论。即使有完全观察到的上下文，也存在一些技术挑战，阻碍了现有的套索融合理论的应用：1）证明在有条件的高斯噪声下的受限特征值条件和2）考虑上下文变量与所选动作之间的依赖性。本文研究了缺失协变量对随机线性匪徒遗憾的影响。我们的工作为拟议算法所产生的协变量概率所产生的遗憾提供了高概率的上限，这表明遗憾的是由于缺失而导致的遗憾，最多$ \ zeta_ {min}^2 $，其中$ \ zeta_ { min} $是在上下文向量观察协变量的最小概率。我们说明了我们的算法，用于实验设计的实际应用来通过连续选择的类别区分DNA探针来收集基因表达数据。

Many modern research fields increasingly rely on collecting and analysing massive, often unstructured, and unwieldy datasets. Consequently, there is growing interest in machine learning and artificial intelligence applications that can harness this `data deluge'. This broad nontechnical overview provides a gentle introduction to machine learning with a specific focus on medical and biological applications. We explain the common types of machine learning algorithms and typical tasks that can be solved, illustrating the basics with concrete examples from healthcare. Lastly, we provide an outlook on open challenges, limitations, and potential impacts of machine-learning-powered medicine.

The detection of anomalies in time series data is crucial in a wide range of applications, such as system monitoring, health care or cyber security. While the vast number of available methods makes selecting the right method for a certain application hard enough, different methods have different strengths, e.g. regarding the type of anomalies they are able to find. In this work, we compare six unsupervised anomaly detection methods with different complexities to answer the questions: Are the more complex methods usually performing better? And are there specific anomaly types that those method are tailored to? The comparison is done on the UCR anomaly archive, a recent benchmark dataset for anomaly detection. We compare the six methods by analyzing the experimental results on a dataset- and anomaly type level after tuning the necessary hyperparameter for each method. Additionally we examine the ability of individual methods to incorporate prior knowledge about the anomalies and analyse the differences of point-wise and sequence wise features. We show with broad experiments, that the classical machine learning methods show a superior performance compared to the deep learning methods across a wide range of anomaly types.

Dialogue models are able to generate coherent and fluent responses, but they can still be challenging to control and may produce non-engaging, unsafe results. This unpredictability diminishes user trust and can hinder the use of the models in the real world. To address this, we introduce DialGuide, a novel framework for controlling dialogue model behavior using natural language rules, or guidelines. These guidelines provide information about the context they are applicable to and what should be included in the response, allowing the models to generate responses that are more closely aligned with the developer's expectations and intent. We evaluate DialGuide on three tasks in open-domain dialogue response generation: guideline selection, response generation, and response entailment verification. Our dataset contains 10,737 positive and 15,467 negative dialogue context-response-guideline triplets across two domains - chit-chat and safety. We provide baseline models for the tasks and benchmark their performance. We also demonstrate that DialGuide is effective in the dialogue safety domain, producing safe and engaging responses that follow developer guidelines.

To train deep learning models, which often outperform traditional approaches, large datasets of a specified medium, e.g., images, are used in numerous areas. However, for light field-specific machine learning tasks, there is a lack of such available datasets. Therefore, we create our own light field datasets, which have great potential for a variety of applications due to the abundance of information in light fields compared to singular images. Using the Unity and C# frameworks, we develop a novel approach for generating large, scalable, and reproducible light field datasets based on customizable hardware configurations to accelerate light field deep learning research.

We consider a sequential decision making task where we are not allowed to evaluate parameters that violate an a priori unknown (safety) constraint. A common approach is to place a Gaussian process prior on the unknown constraint and allow evaluations only in regions that are safe with high probability. Most current methods rely on a discretization of the domain and cannot be directly extended to the continuous case. Moreover, the way in which they exploit regularity assumptions about the constraint introduces an additional critical hyperparameter. In this paper, we propose an information-theoretic safe exploration criterion that directly exploits the GP posterior to identify the most informative safe parameters to evaluate. Our approach is naturally applicable to continuous domains and does not require additional hyperparameters. We theoretically analyze the method and show that we do not violate the safety constraint with high probability and that we explore by learning about the constraint up to arbitrary precision. Empirical evaluations demonstrate improved data-efficiency and scalability.

Counterfactuals are often described as 'retrospective,' focusing on hypothetical alternatives to a realized past. This description relates to an often implicit assumption about the structure and stability of exogenous variables in the system being modeled -- an assumption that is reasonable in many settings where counterfactuals are used. In this work, we consider cases where we might reasonably make a different assumption about exogenous variables, namely, that the exogenous noise terms of each unit do exhibit some unit-specific structure and/or stability. This leads us to a different use of counterfactuals -- a 'forward-looking' rather than 'retrospective' counterfactual. We introduce "counterfactual treatment choice," a type of treatment choice problem that motivates using forward-looking counterfactuals. We then explore how mismatches between interventional versus forward-looking counterfactual approaches to treatment choice, consistent with different assumptions about exogenous noise, can lead to counterintuitive results.

Machine Learning models capable of handling the large datasets collected in the financial world can often become black boxes expensive to run. The quantum computing paradigm suggests new optimization techniques, that combined with classical algorithms, may deliver competitive, faster and more interpretable models. In this work we propose a quantum-enhanced machine learning solution for the prediction of credit rating downgrades, also known as fallen-angels forecasting in the financial risk management field. We implement this solution on a neutral atom Quantum Processing Unit with up to 60 qubits on a real-life dataset. We report competitive performances against the state-of-the-art Random Forest benchmark whilst our model achieves better interpretability and comparable training times. We examine how to improve performance in the near-term validating our ideas with Tensor Networks-based numerical simulations.

Controlled text generation is a very important task in the arena of natural language processing due to its promising applications. In order to achieve this task we mainly introduce the novel soft prompt tuning method of using soft prompts at both encoder and decoder levels together in a T5 model and investigate the performance as the behaviour of an additional soft prompt related to the decoder of a T5 model in controlled text generation remained unexplored. Then we also investigate the feasibility of steering the output of this extended soft prompted T5 model at decoder level and finally analyse the utility of generated text to be used in AI related tasks such as training AI models with an interpretability analysis of the classifier trained with synthetic text, as there is a lack of proper analysis of methodologies in generating properly labelled data to be utilized in AI tasks. Through the performed in-depth intrinsic and extrinsic evaluations of this generation model along with the artificially generated data, we found that this model produced better results compared to the T5 model with a single soft prompt at encoder level and the sentiment classifier trained using this artificially generated data can produce comparable classification results to the results of a classifier trained with real labelled data and also the classifier decision is interpretable with respect to the input text content.