食管障碍的发病机制与食管壁力学有关。因此，要了解各种食管障碍背后的潜在基本机制，将基于食管壁力学的参数映射到与改变的推注途径和超级性IBP对应的生理和病理生理学条件至关重要。在这项工作中，我们提出了一种混合框架，将流体力学和机器学习结合，以识别各种食管障碍的底层物理，并将它们映射到我们称之为虚拟疾病景观（VDL）的参数空间上。一维逆模型处理来自食道诊断装置的输出，称为内窥镜功能腔成像探针（endoflip）来估计食道的机械“健康”，通过预测一组基于机械基的参数，例如食道壁刚度，肌肉收缩食管墙的模式和活跃放松。然后使用基于机械基的参数来训练由改变空间（VAE）组成的神经网络，其产生潜在空间和侧面网络，该侧面网络预测用于估计食道古代结动性的机械工作度量。潜在的矢量以及一组基于基于机械的参数定义VDL并形成与各种食管疾病相对应的簇。 VDL不仅区分不同的疾病，而且还可用于预测疾病进展及时。最后，我们还证明了该框架的临床适用性，用于估算治疗后治疗和追踪患者状况的有效性。

A comprehensive pharmaceutical recommendation system was designed based on the patients and drugs features extracted from Drugs.com and Druglib.com. First, data from these databases were combined, and a dataset of patients and drug information was built. Secondly, the patients and drugs were clustered, and then the recommendation was performed using different ratings provided by patients, and importantly by the knowledge obtained from patients and drug specifications, and considering drug interactions. To the best of our knowledge, we are the first group to consider patients conditions and history in the proposed approach for selecting a specific medicine appropriate for that particular user. Our approach applies artificial intelligence (AI) models for the implementation. Sentiment analysis using natural language processing approaches is employed in pre-processing along with neural network-based methods and recommender system algorithms for modeling the system. In our work, patients conditions and drugs features are used for making two models based on matrix factorization. Then we used drug interaction to filter drugs with severe or mild interactions with other drugs. We developed a deep learning model for recommending drugs by using data from 2304 patients as a training set, and then we used data from 660 patients as our validation set. After that, we used knowledge from critical information about drugs and combined the outcome of the model into a knowledge-based system with the rules obtained from constraints on taking medicine.

We introduce camouflaged data poisoning attacks, a new attack vector that arises in the context of machine unlearning and other settings when model retraining may be induced. An adversary first adds a few carefully crafted points to the training dataset such that the impact on the model's predictions is minimal. The adversary subsequently triggers a request to remove a subset of the introduced points at which point the attack is unleashed and the model's predictions are negatively affected. In particular, we consider clean-label targeted attacks (in which the goal is to cause the model to misclassify a specific test point) on datasets including CIFAR-10, Imagenette, and Imagewoof. This attack is realized by constructing camouflage datapoints that mask the effect of a poisoned dataset.

Psychology research has long explored aspects of human personality such as extroversion, agreeableness and emotional stability. Categorizations like the `Big Five' personality traits are commonly used to assess and diagnose personality types. In this work, we explore the question of whether the perceived personality in language models is exhibited consistently in their language generation. For example, is a language model such as GPT2 likely to respond in a consistent way if asked to go out to a party? We also investigate whether such personality traits can be controlled. We show that when provided different types of contexts (such as personality descriptions, or answers to diagnostic questions about personality traits), language models such as BERT and GPT2 can consistently identify and reflect personality markers in those contexts. This behavior illustrates an ability to be manipulated in a highly predictable way, and frames them as tools for identifying personality traits and controlling personas in applications such as dialog systems. We also contribute a crowd-sourced data-set of personality descriptions of human subjects paired with their `Big Five' personality assessment data, and a data-set of personality descriptions collated from Reddit.

This paper investigates the problem of Named Entity Recognition (NER) for extreme low-resource languages with only a few hundred tagged data samples. NER is a fundamental task in Natural Language Processing (NLP). A critical driver accelerating NER systems' progress is the existence of large-scale language corpora that enable NER systems to achieve outstanding performance in languages such as English and French with abundant training data. However, NER for low-resource languages remains relatively unexplored. In this paper, we introduce Mask Augmented Named Entity Recognition (MANER), a new methodology that leverages the distributional hypothesis of pre-trained masked language models (MLMs) for NER. The <mask> token in pre-trained MLMs encodes valuable semantic contextual information. MANER re-purposes the <mask> token for NER prediction. Specifically, we prepend the <mask> token to every word in a sentence for which we would like to predict the named entity tag. During training, we jointly fine-tune the MLM and a new NER prediction head attached to each <mask> token. We demonstrate that MANER is well-suited for NER in low-resource languages; our experiments show that for 100 languages with as few as 100 training examples, it improves on state-of-the-art methods by up to 48% and by 12% on average on F1 score. We also perform detailed analyses and ablation studies to understand the scenarios that are best-suited to MANER.

A hallmark of human intelligence is the ability to learn new concepts purely from language. Several recent approaches have explored training machine learning models via natural language supervision. However, these approaches fall short in leveraging linguistic quantifiers (such as 'always' or 'rarely') and mimicking humans in compositionally learning complex tasks. Here, we present LaSQuE, a method that can learn zero-shot classifiers from language explanations by using three new strategies - (1) modeling the semantics of linguistic quantifiers in explanations (including exploiting ordinal strength relationships, such as 'always' > 'likely'), (2) aggregating information from multiple explanations using an attention-based mechanism, and (3) model training via curriculum learning. With these strategies, LaSQuE outperforms prior work, showing an absolute gain of up to 7% in generalizing to unseen real-world classification tasks.

Biomedical image segmentation is one of the fastest growing fields which has seen extensive automation through the use of Artificial Intelligence. This has enabled widespread adoption of accurate techniques to expedite the screening and diagnostic processes which would otherwise take several days to finalize. In this paper, we present an end-to-end pipeline to segment lungs from chest X-ray images, training the neural network model on the Japanese Society of Radiological Technology (JSRT) dataset, using UNet to enable faster processing of initial screening for various lung disorders. The pipeline developed can be readily used by medical centers with just the provision of X-Ray images as input. The model will perform the preprocessing, and provide a segmented image as the final output. It is expected that this will drastically reduce the manual effort involved and lead to greater accessibility in resource-constrained locations.

Generating realistic 3D worlds occupied by moving humans has many applications in games, architecture, and synthetic data creation. But generating such scenes is expensive and labor intensive. Recent work generates human poses and motions given a 3D scene. Here, we take the opposite approach and generate 3D indoor scenes given 3D human motion. Such motions can come from archival motion capture or from IMU sensors worn on the body, effectively turning human movement in a "scanner" of the 3D world. Intuitively, human movement indicates the free-space in a room and human contact indicates surfaces or objects that support activities such as sitting, lying or touching. We propose MIME (Mining Interaction and Movement to infer 3D Environments), which is a generative model of indoor scenes that produces furniture layouts that are consistent with the human movement. MIME uses an auto-regressive transformer architecture that takes the already generated objects in the scene as well as the human motion as input, and outputs the next plausible object. To train MIME, we build a dataset by populating the 3D FRONT scene dataset with 3D humans. Our experiments show that MIME produces more diverse and plausible 3D scenes than a recent generative scene method that does not know about human movement. Code and data will be available for research at https://mime.is.tue.mpg.de.

Individual-level data (microdata) that characterizes a population, is essential for studying many real-world problems. However, acquiring such data is not straightforward due to cost and privacy constraints, and access is often limited to aggregated data (macro data) sources. In this study, we examine synthetic data generation as a tool to extrapolate difficult-to-obtain high-resolution data by combining information from multiple easier-to-obtain lower-resolution data sources. In particular, we introduce a framework that uses a combination of univariate and multivariate frequency tables from a given target geographical location in combination with frequency tables from other auxiliary locations to generate synthetic microdata for individuals in the target location. Our method combines the estimation of a dependency graph and conditional probabilities from the target location with the use of a Gaussian copula to leverage the available information from the auxiliary locations. We perform extensive testing on two real-world datasets and demonstrate that our approach outperforms prior approaches in preserving the overall dependency structure of the data while also satisfying the constraints defined on the different variables.

Modern deep learning models are over-parameterized, where the optimization setup strongly affects the generalization performance. A key element of reliable optimization for these systems is the modification of the loss function. Sharpness-Aware Minimization (SAM) modifies the underlying loss function to guide descent methods towards flatter minima, which arguably have better generalization abilities. In this paper, we focus on a variant of SAM known as mSAM, which, during training, averages the updates generated by adversarial perturbations across several disjoint shards of a mini-batch. Recent work suggests that mSAM can outperform SAM in terms of test accuracy. However, a comprehensive empirical study of mSAM is missing from the literature -- previous results have mostly been limited to specific architectures and datasets. To that end, this paper presents a thorough empirical evaluation of mSAM on various tasks and datasets. We provide a flexible implementation of mSAM and compare the generalization performance of mSAM to the performance of SAM and vanilla training on different image classification and natural language processing tasks. We also conduct careful experiments to understand the computational cost of training with mSAM, its sensitivity to hyperparameters and its correlation with the flatness of the loss landscape. Our analysis reveals that mSAM yields superior generalization performance and flatter minima, compared to SAM, across a wide range of tasks without significantly increasing computational costs.