Recent work has reported that AI classifiers trained on audio recordings can accurately predict severe acute respiratory syndrome coronavirus 2 (SARSCoV2) infection status. Here, we undertake a large scale study of audio-based deep learning classifiers, as part of the UK governments pandemic response. We collect and analyse a dataset of audio recordings from 67,842 individuals with linked metadata, including reverse transcription polymerase chain reaction (PCR) test outcomes, of whom 23,514 tested positive for SARS CoV 2. Subjects were recruited via the UK governments National Health Service Test-and-Trace programme and the REal-time Assessment of Community Transmission (REACT) randomised surveillance survey. In an unadjusted analysis of our dataset AI classifiers predict SARS-CoV-2 infection status with high accuracy (Receiver Operating Characteristic Area Under the Curve (ROCAUC) 0.846 [0.838, 0.854]) consistent with the findings of previous studies. However, after matching on measured confounders, such as age, gender, and self reported symptoms, our classifiers performance is much weaker (ROC-AUC 0.619 [0.594, 0.644]). Upon quantifying the utility of audio based classifiers in practical settings, we find them to be outperformed by simple predictive scores based on user reported symptoms.

Since early in the coronavirus disease 2019 (COVID-19) pandemic, there has been interest in using artificial intelligence methods to predict COVID-19 infection status based on vocal audio signals, for example cough recordings. However, existing studies have limitations in terms of data collection and of the assessment of the performances of the proposed predictive models. This paper rigorously assesses state-of-the-art machine learning techniques used to predict COVID-19 infection status based on vocal audio signals, using a dataset collected by the UK Health Security Agency. This dataset includes acoustic recordings and extensive study participant meta-data. We provide guidelines on testing the performance of methods to classify COVID-19 infection status based on acoustic features and we discuss how these can be extended more generally to the development and assessment of predictive methods based on public health datasets.

The UK COVID-19 Vocal Audio Dataset is designed for the training and evaluation of machine learning models that classify SARS-CoV-2 infection status or associated respiratory symptoms using vocal audio. The UK Health Security Agency recruited voluntary participants through the national Test and Trace programme and the REACT-1 survey in England from March 2021 to March 2022, during dominant transmission of the Alpha and Delta SARS-CoV-2 variants and some Omicron variant sublineages. Audio recordings of volitional coughs, exhalations, and speech were collected in the 'Speak up to help beat coronavirus' digital survey alongside demographic, self-reported symptom and respiratory condition data, and linked to SARS-CoV-2 test results. The UK COVID-19 Vocal Audio Dataset represents the largest collection of SARS-CoV-2 PCR-referenced audio recordings to date. PCR results were linked to 70,794 of 72,999 participants and 24,155 of 25,776 positive cases. Respiratory symptoms were reported by 45.62% of participants. This dataset has additional potential uses for bioacoustics research, with 11.30% participants reporting asthma, and 27.20% with linked influenza PCR test results.

Machine learning models are typically evaluated by computing similarity with reference annotations and trained by maximizing similarity with such. Especially in the bio-medical domain, annotations are subjective and suffer from low inter- and intra-rater reliability. Since annotations only reflect the annotation entity's interpretation of the real world, this can lead to sub-optimal predictions even though the model achieves high similarity scores. Here, the theoretical concept of Peak Ground Truth (PGT) is introduced. PGT marks the point beyond which an increase in similarity with the reference annotation stops translating to better Real World Model Performance (RWMP). Additionally, a quantitative technique to approximate PGT by computing inter- and intra-rater reliability is proposed. Finally, three categories of PGT-aware strategies to evaluate and improve model performance are reviewed.

A "heart attack" or myocardial infarction (MI), occurs when an artery supplying blood to the heart is abruptly occluded. The "gold standard" method for imaging MI is Cardiovascular Magnetic Resonance Imaging (MRI), with intravenously administered gadolinium-based contrast (late gadolinium enhancement). However, no "gold standard" fully automated method for the quantification of MI exists. In this work, we propose an end-to-end fully automatic system (MyI-Net) for the detection and quantification of MI in MRI images. This has the potential to reduce the uncertainty due to the technical variability across labs and inherent problems of the data and labels. Our system consists of four processing stages designed to maintain the flow of information across scales. First, features from raw MRI images are generated using feature extractors built on ResNet and MoblieNet architectures. This is followed by the Atrous Spatial Pyramid Pooling (ASPP) to produce spatial information at different scales to preserve more image context. High-level features from ASPP and initial low-level features are concatenated at the third stage and then passed to the fourth stage where spatial information is recovered via up-sampling to produce final image segmentation output into: i) background, ii) heart muscle, iii) blood and iv) scar areas. New models were compared with state-of-art models and manual quantification. Our models showed favorable performance in global segmentation and scar tissue detection relative to state-of-the-art work, including a four-fold better performance in matching scar pixels to contours produced by clinicians.

Graph neural networks (GNN) have become the default machine learning model for relational datasets, including protein interaction networks, biological neural networks, and scientific collaboration graphs. We use tools from statistical physics and random matrix theory to precisely characterize generalization in simple graph convolution networks on the contextual stochastic block model. The derived curves are phenomenologically rich: they explain the distinction between learning on homophilic and heterophilic graphs and they predict double descent whose existence in GNNs has been questioned by recent work. Our results are the first to accurately explain the behavior not only of a stylized graph learning model but also of complex GNNs on messy real-world datasets. To wit, we use our analytic insights about homophily and heterophily to improve performance of state-of-the-art graph neural networks on several heterophilic benchmarks by a simple addition of negative self-loop filters.

In this paper, we propose a new neural network architecture based on the H2 matrix. Even though networks with H2-inspired architecture already exist, and our approach is designed to reduce memory costs and improve performance by taking into account the sparsity template of the H2 matrix. In numerical comparison with alternative neural networks, including the known H2-based ones, our architecture showed itself as beneficial in terms of performance, memory, and scalability.

Existing 3D-aware image synthesis approaches mainly focus on generating a single canonical object and show limited capacity in composing a complex scene containing a variety of objects. This work presents DisCoScene: a 3Daware generative model for high-quality and controllable scene synthesis. The key ingredient of our method is a very abstract object-level representation (i.e., 3D bounding boxes without semantic annotation) as the scene layout prior, which is simple to obtain, general to describe various scene contents, and yet informative to disentangle objects and background. Moreover, it serves as an intuitive user control for scene editing. Based on such a prior, the proposed model spatially disentangles the whole scene into object-centric generative radiance fields by learning on only 2D images with the global-local discrimination. Our model obtains the generation fidelity and editing flexibility of individual objects while being able to efficiently compose objects and the background into a complete scene. We demonstrate state-of-the-art performance on many scene datasets, including the challenging Waymo outdoor dataset. Project page: https://snap-research.github.io/discoscene/

Semi-supervised learning (SSL) has made significant strides in the field of remote sensing. Finding a large number of labeled datasets for SSL methods is uncommon, and manually labeling datasets is expensive and time-consuming. Furthermore, accurately identifying remote sensing satellite images is more complicated than it is for conventional images. Class-imbalanced datasets are another prevalent phenomenon, and models trained on these become biased towards the majority classes. This becomes a critical issue with an SSL model's subpar performance. We aim to address the issue of labeling unlabeled data and also solve the model bias problem due to imbalanced datasets while achieving better accuracy. To accomplish this, we create "artificial" labels and train a model to have reasonable accuracy. We iteratively redistribute the classes through resampling using a distribution alignment technique. We use a variety of class imbalanced satellite image datasets: EuroSAT, UCM, and WHU-RS19. On UCM balanced dataset, our method outperforms previous methods MSMatch and FixMatch by 1.21% and 0.6%, respectively. For imbalanced EuroSAT, our method outperforms MSMatch and FixMatch by 1.08% and 1%, respectively. Our approach significantly lessens the requirement for labeled data, consistently outperforms alternative approaches, and resolves the issue of model bias caused by class imbalance in datasets.

Fine-tuning a Pre-trained Language Model (PLM) on a specific downstream task has been a well-known paradigm in Natural Language Processing. However, with the ever-growing size of PLMs, training the entire model on several downstream tasks becomes very expensive and resource-hungry. Recently, different Parameter Efficient Tuning (PET) techniques are proposed to improve the efficiency of fine-tuning PLMs. One popular category of PET methods is the low-rank adaptation methods which insert learnable truncated SVD modules into the original model either sequentially or in parallel. However, low-rank decomposition suffers from limited representation power. In this work, we address this problem using the Kronecker product instead of the low-rank representation. We introduce KronA, a Kronecker product-based adapter module for efficient fine-tuning of Transformer-based PLMs. We apply the proposed methods for fine-tuning T5 on the GLUE benchmark to show that incorporating the Kronecker-based modules can outperform state-of-the-art PET methods.