Time-series anomaly detection is an important task and has been widely applied in the industry. Since manual data annotation is expensive and inefficient, most applications adopt unsupervised anomaly detection methods, but the results are usually sub-optimal and unsatisfactory to end customers. Weak supervision is a promising paradigm for obtaining considerable labels in a low-cost way, which enables the customers to label data by writing heuristic rules rather than annotating each instance individually. However, in the time-series domain, it is hard for people to write reasonable labeling functions as the time-series data is numerically continuous and difficult to be understood. In this paper, we propose a Label-Efficient Interactive Time-Series Anomaly Detection (LEIAD) system, which enables a user to improve the results of unsupervised anomaly detection by performing only a small amount of interactions with the system. To achieve this goal, the system integrates weak supervision and active learning collaboratively while generating labeling functions automatically using only a few labeled data. All of these techniques are complementary and can promote each other in a reinforced manner. We conduct experiments on three time-series anomaly detection datasets, demonstrating that the proposed system is superior to existing solutions in both weak supervision and active learning areas. Also, the system has been tested in a real scenario in industry to show its practicality.

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet, a supervised deep-learning model to predict the fitness for protein mutants by leveraging both sequence and structure information, and exploiting attention mechanism. Our model integrates local evolutionary context from homologous sequences, the global evolutionary context encoding rich semantic from the universal protein sequence space and the structure information accounting for the microenvironment around each residue in a protein. We show that SESNet outperforms state-of-the-art models for predicting the sequence-function relationship on 26 deep mutational scanning datasets. More importantly, we propose a data augmentation strategy by leveraging the data from unsupervised models to pre-train our model. After that, our model can achieve strikingly high accuracy in prediction of the fitness of protein mutants, especially for the higher order variants (> 4 mutation sites), when finetuned by using only a small number of experimental mutation data (<50). The strategy proposed is of great practical value as the required experimental effort, i.e., producing a few tens of experimental mutation data on a given protein, is generally affordable by an ordinary biochemical group and can be applied on almost any protein.

During X-ray computed tomography (CT) scanning, metallic implants carrying with patients often lead to adverse artifacts in the captured CT images and then impair the clinical treatment. Against this metal artifact reduction (MAR) task, the existing deep-learning-based methods have gained promising reconstruction performance. Nevertheless, there is still some room for further improvement of MAR performance and generalization ability, since some important prior knowledge underlying this specific task has not been fully exploited. Hereby, in this paper, we carefully analyze the characteristics of metal artifacts and propose an orientation-shared convolution representation strategy to adapt the physical prior structures of artifacts, i.e., rotationally symmetrical streaking patterns. The proposed method rationally adopts Fourier-series-expansion-based filter parametrization in artifact modeling, which can better separate artifacts from anatomical tissues and boost the model generalizability. Comprehensive experiments executed on synthesized and clinical datasets show the superiority of our method in detail preservation beyond the current representative MAR methods. Code will be available at \url{https://github.com/hongwang01/OSCNet}

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Sequential recommendation is an important task to predict the next-item to access based on a sequence of interacted items. Most existing works learn user preference as the transition pattern from the previous item to the next one, ignoring the time interval between these two items. However, we observe that the time interval in a sequence may vary significantly different, and thus result in the ineffectiveness of user modeling due to the issue of \emph{preference drift}. In fact, we conducted an empirical study to validate this observation, and found that a sequence with uniformly distributed time interval (denoted as uniform sequence) is more beneficial for performance improvement than that with greatly varying time interval. Therefore, we propose to augment sequence data from the perspective of time interval, which is not studied in the literature. Specifically, we design five operators (Ti-Crop, Ti-Reorder, Ti-Mask, Ti-Substitute, Ti-Insert) to transform the original non-uniform sequence to uniform sequence with the consideration of variance of time intervals. Then, we devise a control strategy to execute data augmentation on item sequences in different lengths. Finally, we implement these improvements on a state-of-the-art model CoSeRec and validate our approach on four real datasets. The experimental results show that our approach reaches significantly better performance than the other 11 competing methods. Our implementation is available: https://github.com/KingGugu/TiCoSeRec.

Although DETR-based 3D detectors can simplify the detection pipeline and achieve direct sparse predictions, their performance still lags behind dense detectors with post-processing for 3D object detection from point clouds. DETRs usually adopt a larger number of queries than GTs (e.g., 300 queries v.s. 40 objects in Waymo) in a scene, which inevitably incur many false positives during inference. In this paper, we propose a simple yet effective sparse 3D detector, named Query Contrast Voxel-DETR (ConQueR), to eliminate the challenging false positives, and achieve more accurate and sparser predictions. We observe that most false positives are highly overlapping in local regions, caused by the lack of explicit supervision to discriminate locally similar queries. We thus propose a Query Contrast mechanism to explicitly enhance queries towards their best-matched GTs over all unmatched query predictions. This is achieved by the construction of positive and negative GT-query pairs for each GT, and a contrastive loss to enhance positive GT-query pairs against negative ones based on feature similarities. ConQueR closes the gap of sparse and dense 3D detectors, and reduces up to ~60% false positives. Our single-frame ConQueR achieves new state-of-the-art (sota) 71.6 mAPH/L2 on the challenging Waymo Open Dataset validation set, outperforming previous sota methods (e.g., PV-RCNN++) by over 2.0 mAPH/L2.

Previous studies have explored generating accurately lip-synced talking faces for arbitrary targets given audio conditions. However, most of them deform or generate the whole facial area, leading to non-realistic results. In this work, we delve into the formulation of altering only the mouth shapes of the target person. This requires masking a large percentage of the original image and seamlessly inpainting it with the aid of audio and reference frames. To this end, we propose the Audio-Visual Context-Aware Transformer (AV-CAT) framework, which produces accurate lip-sync with photo-realistic quality by predicting the masked mouth shapes. Our key insight is to exploit desired contextual information provided in audio and visual modalities thoroughly with delicately designed Transformers. Specifically, we propose a convolution-Transformer hybrid backbone and design an attention-based fusion strategy for filling the masked parts. It uniformly attends to the textural information on the unmasked regions and the reference frame. Then the semantic audio information is involved in enhancing the self-attention computation. Additionally, a refinement network with audio injection improves both image and lip-sync quality. Extensive experiments validate that our model can generate high-fidelity lip-synced results for arbitrary subjects.

This paper presents an algorithm to solve the Soft k-Means problem globally. Unlike Fuzzy c-Means, Soft k-Means (SkM) has a matrix factorization-type objective and has been shown to have a close relation with the popular probability decomposition-type clustering methods, e.g., Left Stochastic Clustering (LSC). Though some work has been done for solving the Soft k-Means problem, they usually use an alternating minimization scheme or the projected gradient descent method, which cannot guarantee global optimality since the non-convexity of SkM. In this paper, we present a sufficient condition for a feasible solution of Soft k-Means problem to be globally optimal and show the output of the proposed algorithm satisfies it. Moreover, for the Soft k-Means problem, we provide interesting discussions on stability, solutions non-uniqueness, and connection with LSC. Then, a new model, named Minimal Volume Soft k-Means (MVSkM), is proposed to address the solutions non-uniqueness issue. Finally, experimental results support our theoretical results.

This paper focuses on the prevalent performance imbalance in the stages of incremental learning. To avoid obvious stage learning bottlenecks, we propose a brand-new stage-isolation based incremental learning framework, which leverages a series of stage-isolated classifiers to perform the learning task of each stage without the interference of others. To be concrete, to aggregate multiple stage classifiers as a uniform one impartially, we first introduce a temperature-controlled energy metric for indicating the confidence score levels of the stage classifiers. We then propose an anchor-based energy self-normalization strategy to ensure the stage classifiers work at the same energy level. Finally, we design a voting-based inference augmentation strategy for robust inference. The proposed method is rehearsal free and can work for almost all continual learning scenarios. We evaluate the proposed method on four large benchmarks. Extensive results demonstrate the superiority of the proposed method in setting up new state-of-the-art overall performance. \emph{Code is available at} \url{https://github.com/iamwangyabin/ESN}.

This study proposes an improved end-to-end multi-target tracking algorithm that adapts to multi-view multi-scale scenes based on the self-attentive mechanism of the transformer's encoder-decoder structure. A multi-dimensional feature extraction backbone network is combined with a self-built semantic raster map, which is stored in the encoder for correlation and generates target position encoding and multi-dimensional feature vectors. The decoder incorporates four methods: spatial clustering and semantic filtering of multi-view targets, dynamic matching of multi-dimensional features, space-time logic-based multi-target tracking, and space-time convergence network (STCN)-based parameter passing. Through the fusion of multiple decoding methods, muti-camera targets are tracked in three dimensions: temporal logic, spatial logic, and feature matching. For the MOT17 dataset, this study's method significantly outperforms the current state-of-the-art method MiniTrackV2 [49] by 2.2% to 0.836 on Multiple Object Tracking Accuracy(MOTA) metric. Furthermore, this study proposes a retrospective mechanism for the first time, and adopts a reverse-order processing method to optimise the historical mislabeled targets for improving the Identification F1-score(IDF1). For the self-built dataset OVIT-MOT01, the IDF1 improves from 0.948 to 0.967, and the Multi-camera Tracking Accuracy(MCTA) improves from 0.878 to 0.909, which significantly improves the continuous tracking accuracy and scene adaptation. This research method introduces a new attentional tracking paradigm which is able to achieve state-of-the-art performance on multi-target tracking (MOT17 and OVIT-MOT01) tasks.