Federated learning is a collaborative model training method by iterating model updates at multiple clients and aggregation of the updates at a central server. Device and statistical heterogeneity of the participating clients cause performance degradation so that an appropriate weight should be assigned per client in the server's aggregation phase. This paper employs deep unfolding to learn the weights that adapt to the heterogeneity, which gives the model with high accuracy on uniform test data. The results of numerical experiments indicate the high performance of the proposed method and the interpretable behavior of the learned weights.
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基于有效干预措施的早期疾病检测和预防方法正在引起人们的注意。机器学习技术通过捕获多元数据中的个体差异来实现精确的疾病预测。精确医学的进展表明,在个人层面的健康数据中存在实质性异质性,并且复杂的健康因素与慢性疾病的发展有关。但是,由于多种生物标志物之间的复杂关系,确定跨疾病发作过程中的个体生理状态变化仍然是一个挑战。在这里,我们介绍了健康疾病阶段图(HDPD),它通过可视化在疾病进展过程早期波动的多种生物标志物的边界值来代表个人健康状态。在HDPD中,未来的发作预测是通过扰动多个生物标志物值的情况来表示的,同时考虑变量之间的依赖性。我们从3,238个个体的纵向健康检查队列中构建了11种非传染性疾病(NCD)的HDPD,其中包括3,215个测量项目和遗传数据。 HDPD中非发病区域的生物标志物值的改善显着阻止了11个NCD中的7个未来的疾病发作。我们的结果表明,HDPD可以在发作过程中代表单个生理状态,并用作预防疾病的干预目标。
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