大型预先训练的语言模型可以在可以在一个可以“单通”中的任务上进行非常好，例如生成现实文本或合成计算机程序。但是，他们与需要无限的多步计算的任务斗争，例如添加整数或执行程序。令人惊讶的是，我们发现这些相同的模型能够执行复杂的多步计算 - 即使在少量射门中，当被要求执行操作“一步一步”时，表示中间计算的结果。特别是，我们通过询问它们将中间计算步骤发出到“ScratchPad”来执行变压器来执行多步计算。在一系列越来越复杂的任务范围内，从加入任意程序的执行范围，我们表明Scratchpads显着提高了语言模型执行多步计算的能力。

Using 3D CNNs on high resolution medical volumes is very computationally demanding, especially for large datasets like the UK Biobank which aims to scan 100,000 subjects. Here we demonstrate that using 2D CNNs on a few 2D projections (representing mean and standard deviation across axial, sagittal and coronal slices) of the 3D volumes leads to reasonable test accuracy when predicting the age from brain volumes. Using our approach, one training epoch with 20,324 subjects takes 40 - 70 seconds using a single GPU, which is almost 100 times faster compared to a small 3D CNN. These results are important for researchers who do not have access to expensive GPU hardware for 3D CNNs.

从简短的问题实例推断出较长的实例的能力是推理任务中分布概括的一种重要形式，并且在较长的问题实例很少见的数据集中学习时至关重要。这些包括定理证明，解决定量数学问题以及阅读/总结小说。在本文中，我们进行了仔细的经验研究，以探讨基于变压器的语言模型的长度概括能力。我们首先确定长度泛化任务上的天真固定变压器显示出与模型量表无关的显着泛化缺陷。然后，我们表明，将预处理的大语言模型与SCRATCHPAD提示（要求模型在产生答案之前输出解决方案步骤）相结合，从而巨大的长度概括改进。我们对每种学习方式进行了仔细的失败分析，并确定了常见的错误来源，这些错误来源突出了将语言模型的机会与更长的问题概括的能力。

语言模型在需要自然语言理解的各种任务上取得了非凡的表现。然而，最先进的模型通常在需要定量推理的任务上挣扎，例如在大学一级解决数学，科学和工程问题。为了帮助缩小这一差距，我们介绍了Minerva，Minerva是一种在一般自然语言数据上鉴定的大型语言模型，并进一步培训了技术内容。该模型在不使用外部工具的情况下实现了技术基准测试的最新性能。我们还评估了我们在需要定量推理的物理学，生物学，化学，经济学和其他科学方面的200多个本科生问题上评估我们的模型，并发现该模型可以正确回答其中几乎三分之一。

语言模型既展示了定量的改进，又展示了新的定性功能，随着规模的增加。尽管它们具有潜在的变革性影响，但这些新能力的特征却很差。为了为未来的研究提供信息，为破坏性的新模型能力做准备，并改善社会有害的效果，至关重要的是，我们必须了解目前和近乎未来的能力和语言模型的局限性。为了应对这一挑战，我们介绍了超越模仿游戏基准（Big Bench）。 Big Bench目前由204个任务组成，由132家机构的442位作者贡献。任务主题是多样的，从语言学，儿童发展，数学，常识性推理，生物学，物理学，社会偏见，软件开发等等。 Big-Bench专注于被认为超出当前语言模型的功能的任务。我们评估了OpenAI的GPT型号，Google内部密集变压器体系结构和大型基础上的开关稀疏变压器的行为，跨越了数百万到数十亿个参数。此外，一个人类专家评估者团队执行了所有任务，以提供强大的基准。研究结果包括：模型性能和校准都随规模改善，但绝对的术语（以及与评估者的性能相比）；在模型类中的性能非常相似，尽管带有稀疏性。逐渐和预测的任务通常涉及大量知识或记忆成分，而在临界规模上表现出“突破性”行为的任务通常涉及多个步骤或组成部分或脆性指标；社交偏见通常会随着含糊不清的环境而随着规模而增加，但这可以通过提示来改善。

Data-driven models such as neural networks are being applied more and more to safety-critical applications, such as the modeling and control of cyber-physical systems. Despite the flexibility of the approach, there are still concerns about the safety of these models in this context, as well as the need for large amounts of potentially expensive data. In particular, when long-term predictions are needed or frequent measurements are not available, the open-loop stability of the model becomes important. However, it is difficult to make such guarantees for complex black-box models such as neural networks, and prior work has shown that model stability is indeed an issue. In this work, we consider an aluminum extraction process where measurements of the internal state of the reactor are time-consuming and expensive. We model the process using neural networks and investigate the role of including skip connections in the network architecture as well as using l1 regularization to induce sparse connection weights. We demonstrate that these measures can greatly improve both the accuracy and the stability of the models for datasets of varying sizes.

We test the performance of GAN models for lip-synchronization. For this, we reimplement LipGAN in Pytorch, train it on the dataset GRID and compare it to our own variation, L1WGAN-GP, adapted to the LipGAN architecture and also trained on GRID.

High content imaging assays can capture rich phenotypic response data for large sets of compound treatments, aiding in the characterization and discovery of novel drugs. However, extracting representative features from high content images that can capture subtle nuances in phenotypes remains challenging. The lack of high-quality labels makes it difficult to achieve satisfactory results with supervised deep learning. Self-Supervised learning methods, which learn from automatically generated labels has shown great success on natural images, offer an attractive alternative also to microscopy images. However, we find that self-supervised learning techniques underperform on high content imaging assays. One challenge is the undesirable domain shifts present in the data known as batch effects, which may be caused by biological noise or uncontrolled experimental conditions. To this end, we introduce Cross-Domain Consistency Learning (CDCL), a novel approach that is able to learn in the presence of batch effects. CDCL enforces the learning of biological similarities while disregarding undesirable batch-specific signals, which leads to more useful and versatile representations. These features are organised according to their morphological changes and are more useful for downstream tasks - such as distinguishing treatments and mode of action.

Objective: Imbalances of the electrolyte concentration levels in the body can lead to catastrophic consequences, but accurate and accessible measurements could improve patient outcomes. While blood tests provide accurate measurements, they are invasive and the laboratory analysis can be slow or inaccessible. In contrast, an electrocardiogram (ECG) is a widely adopted tool which is quick and simple to acquire. However, the problem of estimating continuous electrolyte concentrations directly from ECGs is not well-studied. We therefore investigate if regression methods can be used for accurate ECG-based prediction of electrolyte concentrations. Methods: We explore the use of deep neural networks (DNNs) for this task. We analyze the regression performance across four electrolytes, utilizing a novel dataset containing over 290000 ECGs. For improved understanding, we also study the full spectrum from continuous predictions to binary classification of extreme concentration levels. To enhance clinical usefulness, we finally extend to a probabilistic regression approach and evaluate different uncertainty estimates. Results: We find that the performance varies significantly between different electrolytes, which is clinically justified in the interplay of electrolytes and their manifestation in the ECG. We also compare the regression accuracy with that of traditional machine learning models, demonstrating superior performance of DNNs. Conclusion: Discretization can lead to good classification performance, but does not help solve the original problem of predicting continuous concentration levels. While probabilistic regression demonstrates potential practical usefulness, the uncertainty estimates are not particularly well-calibrated. Significance: Our study is a first step towards accurate and reliable ECG-based prediction of electrolyte concentration levels.

The distributed representation of symbols is one of the key technologies in machine learning systems today, playing a pivotal role in modern natural language processing. Traditional word embeddings associate a separate vector with each word. While this approach is simple and leads to good performance, it requires a lot of memory for representing a large vocabulary. To reduce the memory footprint, the default embedding layer in spaCy is a hash embeddings layer. It is a stochastic approximation of traditional embeddings that provides unique vectors for a large number of words without explicitly storing a separate vector for each of them. To be able to compute meaningful representations for both known and unknown words, hash embeddings represent each word as a summary of the normalized word form, subword information and word shape. Together, these features produce a multi-embedding of a word. In this technical report we lay out a bit of history and introduce the embedding methods in spaCy in detail. Second, we critically evaluate the hash embedding architecture with multi-embeddings on Named Entity Recognition datasets from a variety of domains and languages. The experiments validate most key design choices behind spaCy's embedders, but we also uncover a few surprising results.