深度神经网络（DNN）对于对培训期间的样品大大减少的课程进行更多错误是臭名昭着的。这种类别不平衡在临床应用中普遍存在，并且对处理非常重要，因为样品较少的类通常对应于临界病例（例如，癌症），其中错误分类可能具有严重后果。不要错过这种情况，通过设定更高的阈值，需要以高真正的阳性率（TPRS）运行二进制分类器，但这是类别不平衡问题的非常高的假阳性率（FPRS）的成本。在课堂失衡下的现有方法通常不会考虑到这一点。我们认为，通过在高TPRS处于阳性的错误分类时强调减少FPRS，应提高预测准确性，即赋予阳性，即批判性，类样本与更高的成本相关。为此，我们将DNN的训练训练为二进制分类作为约束优化问题，并引入一种新的约束，可以通过在高TPR处优先考虑FPR减少来强制ROC曲线（AUC）下强制实施最大面积的新约束。我们使用增强拉格朗日方法（ALM）解决了由此产生的受限优化问题。超越二进制文件，我们还提出了两个可能的延长了多级分类问题的建议约束。我们使用内部医学成像数据集，CIFAR10和CIFAR100呈现基于图像的二元和多级分类应用的实验结果。我们的结果表明，该方法通过在关键类别的准确性上获得了大多数病例的拟议方法，同时降低了非关键类别样本的错误分类率。

Large language models (LLMs) have demonstrated impressive capabilities in natural language understanding and generation, but the quality bar for medical and clinical applications is high. Today, attempts to assess models' clinical knowledge typically rely on automated evaluations on limited benchmarks. There is no standard to evaluate model predictions and reasoning across a breadth of tasks. To address this, we present MultiMedQA, a benchmark combining six existing open question answering datasets spanning professional medical exams, research, and consumer queries; and HealthSearchQA, a new free-response dataset of medical questions searched online. We propose a framework for human evaluation of model answers along multiple axes including factuality, precision, possible harm, and bias. In addition, we evaluate PaLM (a 540-billion parameter LLM) and its instruction-tuned variant, Flan-PaLM, on MultiMedQA. Using a combination of prompting strategies, Flan-PaLM achieves state-of-the-art accuracy on every MultiMedQA multiple-choice dataset (MedQA, MedMCQA, PubMedQA, MMLU clinical topics), including 67.6% accuracy on MedQA (US Medical License Exam questions), surpassing prior state-of-the-art by over 17%. However, human evaluation reveals key gaps in Flan-PaLM responses. To resolve this we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars. The resulting model, Med-PaLM, performs encouragingly, but remains inferior to clinicians. We show that comprehension, recall of knowledge, and medical reasoning improve with model scale and instruction prompt tuning, suggesting the potential utility of LLMs in medicine. Our human evaluations reveal important limitations of today's models, reinforcing the importance of both evaluation frameworks and method development in creating safe, helpful LLM models for clinical applications.

National Association of Securities Dealers Automated Quotations(NASDAQ) is an American stock exchange based. It is one of the most valuable stock economic indices in the world and is located in New York City \cite{pagano2008quality}. The volatility of the stock market and the influence of economic indicators such as crude oil, gold, and the dollar in the stock market, and NASDAQ shares are also affected and have a volatile and chaotic nature \cite{firouzjaee2022lstm}.In this article, we have examined the effect of oil, dollar, gold, and the volatility of the stock market in the economic market, and then we have also examined the effect of these indicators on NASDAQ stocks. Then we started to analyze the impact of the feedback on the past prices of NASDAQ stocks and its impact on the current price. Using PCA and Linear Regression algorithm, we have designed an optimal dynamic learning experience for modeling these stocks. The results obtained from the quantitative analysis are consistent with the results of the qualitative analysis of economic studies, and the modeling done with the optimal dynamic experience of machine learning justifies the current price of NASDAQ shares.

Neural Radiance Fields (NeRFs) are emerging as a ubiquitous scene representation that allows for novel view synthesis. Increasingly, NeRFs will be shareable with other people. Before sharing a NeRF, though, it might be desirable to remove personal information or unsightly objects. Such removal is not easily achieved with the current NeRF editing frameworks. We propose a framework to remove objects from a NeRF representation created from an RGB-D sequence. Our NeRF inpainting method leverages recent work in 2D image inpainting and is guided by a user-provided mask. Our algorithm is underpinned by a confidence based view selection procedure. It chooses which of the individual 2D inpainted images to use in the creation of the NeRF, so that the resulting inpainted NeRF is 3D consistent. We show that our method for NeRF editing is effective for synthesizing plausible inpaintings in a multi-view coherent manner. We validate our approach using a new and still-challenging dataset for the task of NeRF inpainting.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

The study of the attention mechanism has sparked interest in many fields, such as language modeling and machine translation. Although its patterns have been exploited to perform different tasks, from neural network understanding to textual alignment, no previous work has analysed the encoder-decoder attention behavior in speech translation (ST) nor used it to improve ST on a specific task. In this paper, we fill this gap by proposing an attention-based policy (EDAtt) for simultaneous ST (SimulST) that is motivated by an analysis of the existing attention relations between audio input and textual output. Its goal is to leverage the encoder-decoder attention scores to guide inference in real time. Results on en->{de, es} show that the EDAtt policy achieves overall better results compared to the SimulST state of the art, especially in terms of computational-aware latency.

The underlying dynamics and patterns of 3D surface meshes deforming over time can be discovered by unsupervised learning, especially autoencoders, which calculate low-dimensional embeddings of the surfaces. To study the deformation patterns of unseen shapes by transfer learning, we want to train an autoencoder that can analyze new surface meshes without training a new network. Here, most state-of-the-art autoencoders cannot handle meshes of different connectivity and therefore have limited to no generalization capacities to new meshes. Also, reconstruction errors strongly increase in comparison to the errors for the training shapes. To address this, we propose a novel spectral CoSMA (Convolutional Semi-Regular Mesh Autoencoder) network. This patch-based approach is combined with a surface-aware training. It reconstructs surfaces not presented during training and generalizes the deformation behavior of the surfaces' patches. The novel approach reconstructs unseen meshes from different datasets in superior quality compared to state-of-the-art autoencoders that have been trained on these shapes. Our transfer learning errors on unseen shapes are 40% lower than those from models learned directly on the data. Furthermore, baseline autoencoders detect deformation patterns of unseen mesh sequences only for the whole shape. In contrast, due to the employed regional patches and stable reconstruction quality, we can localize where on the surfaces these deformation patterns manifest.

The GLOM architecture proposed by Hinton [2021] is a recurrent neural network for parsing an image into a hierarchy of wholes and parts. When a part is ambiguous, GLOM assumes that the ambiguity can be resolved by allowing the part to make multi-modal predictions for the pose and identity of the whole to which it belongs and then using attention to similar predictions coming from other possibly ambiguous parts to settle on a common mode that is predicted by several different parts. In this study, we describe a highly simplified version of GLOM that allows us to assess the effectiveness of this way of dealing with ambiguity. Our results show that, with supervised training, GLOM is able to successfully form islands of very similar embedding vectors for all of the locations occupied by the same object and it is also robust to strong noise injections in the input and to out-of-distribution input transformations.

Graph neural networks (GNNs) have been utilized for various natural language processing (NLP) tasks lately. The ability to encode corpus-wide features in graph representation made GNN models popular in various tasks such as document classification. One major shortcoming of such models is that they mainly work on homogeneous graphs, while representing text datasets as graphs requires several node types which leads to a heterogeneous schema. In this paper, we propose a transductive hybrid approach composed of an unsupervised node representation learning model followed by a node classification/edge prediction model. The proposed model is capable of processing heterogeneous graphs to produce unified node embeddings which are then utilized for node classification or link prediction as the downstream task. The proposed model is developed to classify stock market technical analysis reports, which to our knowledge is the first work in this domain. Experiments, which are carried away using a constructed dataset, demonstrate the ability of the model in embedding extraction and the downstream tasks.

Artificial intelligence methods including deep neural networks (DNN) can provide rapid molecular classification of tumors from routine histology with accuracy that matches or exceeds human pathologists. Discerning how neural networks make their predictions remains a significant challenge, but explainability tools help provide insights into what models have learned when corresponding histologic features are poorly defined. Here, we present a method for improving explainability of DNN models using synthetic histology generated by a conditional generative adversarial network (cGAN). We show that cGANs generate high-quality synthetic histology images that can be leveraged for explaining DNN models trained to classify molecularly-subtyped tumors, exposing histologic features associated with molecular state. Fine-tuning synthetic histology through class and layer blending illustrates nuanced morphologic differences between tumor subtypes. Finally, we demonstrate the use of synthetic histology for augmenting pathologist-in-training education, showing that these intuitive visualizations can reinforce and improve understanding of histologic manifestations of tumor biology.