U-shaped networks are widely used in various medical image tasks, such as segmentation, restoration and reconstruction, but most of them usually rely on centralized learning and thus ignore privacy issues. To address the privacy concerns, federated learning (FL) and split learning (SL) have attracted increasing attention. However, it is hard for both FL and SL to balance the local computational cost, model privacy and parallel training simultaneously. To achieve this goal, in this paper, we propose Robust Split Federated Learning (RoS-FL) for U-shaped medical image networks, which is a novel hybrid learning paradigm of FL and SL. Previous works cannot preserve the data privacy, including the input, model parameters, label and output simultaneously. To effectively deal with all of them, we design a novel splitting method for U-shaped medical image networks, which splits the network into three parts hosted by different parties. Besides, the distributed learning methods usually suffer from a drift between local and global models caused by data heterogeneity. Based on this consideration, we propose a dynamic weight correction strategy (\textbf{DWCS}) to stabilize the training process and avoid model drift. Specifically, a weight correction loss is designed to quantify the drift between the models from two adjacent communication rounds. By minimizing this loss, a correction model is obtained. Then we treat the weighted sum of correction model and final round models as the result. The effectiveness of the proposed RoS-FL is supported by extensive experimental results on different tasks. Related codes will be released at https://github.com/Zi-YuanYang/RoS-FL.

In this work, we propose MEDICO, a Multi-viEw Deep generative model for molecule generation, structural optimization, and the SARS-CoV-2 Inhibitor disCOvery. To the best of our knowledge, MEDICO is the first-of-this-kind graph generative model that can generate molecular graphs similar to the structure of targeted molecules, with a multi-view representation learning framework to sufficiently and adaptively learn comprehensive structural semantics from targeted molecular topology and geometry. We show that our MEDICO significantly outperforms the state-of-the-art methods in generating valid, unique, and novel molecules under benchmarking comparisons. In particular, we showcase the multi-view deep learning model enables us to generate not only the molecules structurally similar to the targeted molecules but also the molecules with desired chemical properties, demonstrating the strong capability of our model in exploring the chemical space deeply. Moreover, case study results on targeted molecule generation for the SARS-CoV-2 main protease (Mpro) show that by integrating molecule docking into our model as chemical priori, we successfully generate new small molecules with desired drug-like properties for the Mpro, potentially accelerating the de novo design of Covid-19 drugs. Further, we apply MEDICO to the structural optimization of three well-known Mpro inhibitors (N3, 11a, and GC376) and achieve ~88% improvement in their binding affinity to Mpro, demonstrating the application value of our model for the development of therapeutics for SARS-CoV-2 infection.

One-shot segmentation of brain tissues is typically a dual-model iterative learning: a registration model (reg-model) warps a carefully-labeled atlas onto unlabeled images to initialize their pseudo masks for training a segmentation model (seg-model); the seg-model revises the pseudo masks to enhance the reg-model for a better warping in the next iteration. However, there is a key weakness in such dual-model iteration that the spatial misalignment inevitably caused by the reg-model could misguide the seg-model, which makes it converge on an inferior segmentation performance eventually. In this paper, we propose a novel image-aligned style transformation to reinforce the dual-model iterative learning for robust one-shot segmentation of brain tissues. Specifically, we first utilize the reg-model to warp the atlas onto an unlabeled image, and then employ the Fourier-based amplitude exchange with perturbation to transplant the style of the unlabeled image into the aligned atlas. This allows the subsequent seg-model to learn on the aligned and style-transferred copies of the atlas instead of unlabeled images, which naturally guarantees the correct spatial correspondence of an image-mask training pair, without sacrificing the diversity of intensity patterns carried by the unlabeled images. Furthermore, we introduce a feature-aware content consistency in addition to the image-level similarity to constrain the reg-model for a promising initialization, which avoids the collapse of image-aligned style transformation in the first iteration. Experimental results on two public datasets demonstrate 1) a competitive segmentation performance of our method compared to the fully-supervised method, and 2) a superior performance over other state-of-the-art with an increase of average Dice by up to 4.67%. The source code is available at: https://github.com/JinxLv/One-shot-segmentation-via-IST.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Video super-resolution is one of the most popular tasks on mobile devices, being widely used for an automatic improvement of low-bitrate and low-resolution video streams. While numerous solutions have been proposed for this problem, they are usually quite computationally demanding, demonstrating low FPS rates and power efficiency on mobile devices. In this Mobile AI challenge, we address this problem and propose the participants to design an end-to-end real-time video super-resolution solution for mobile NPUs optimized for low energy consumption. The participants were provided with the REDS training dataset containing video sequences for a 4X video upscaling task. The runtime and power efficiency of all models was evaluated on the powerful MediaTek Dimensity 9000 platform with a dedicated AI processing unit capable of accelerating floating-point and quantized neural networks. All proposed solutions are fully compatible with the above NPU, demonstrating an up to 500 FPS rate and 0.2 [Watt / 30 FPS] power consumption. A detailed description of all models developed in the challenge is provided in this paper.

Image super-resolution is a common task on mobile and IoT devices, where one often needs to upscale and enhance low-resolution images and video frames. While numerous solutions have been proposed for this problem in the past, they are usually not compatible with low-power mobile NPUs having many computational and memory constraints. In this Mobile AI challenge, we address this problem and propose the participants to design an efficient quantized image super-resolution solution that can demonstrate a real-time performance on mobile NPUs. The participants were provided with the DIV2K dataset and trained INT8 models to do a high-quality 3X image upscaling. The runtime of all models was evaluated on the Synaptics VS680 Smart Home board with a dedicated edge NPU capable of accelerating quantized neural networks. All proposed solutions are fully compatible with the above NPU, demonstrating an up to 60 FPS rate when reconstructing Full HD resolution images. A detailed description of all models developed in the challenge is provided in this paper.

The role of mobile cameras increased dramatically over the past few years, leading to more and more research in automatic image quality enhancement and RAW photo processing. In this Mobile AI challenge, the target was to develop an efficient end-to-end AI-based image signal processing (ISP) pipeline replacing the standard mobile ISPs that can run on modern smartphone GPUs using TensorFlow Lite. The participants were provided with a large-scale Fujifilm UltraISP dataset consisting of thousands of paired photos captured with a normal mobile camera sensor and a professional 102MP medium-format FujiFilm GFX100 camera. The runtime of the resulting models was evaluated on the Snapdragon's 8 Gen 1 GPU that provides excellent acceleration results for the majority of common deep learning ops. The proposed solutions are compatible with all recent mobile GPUs, being able to process Full HD photos in less than 20-50 milliseconds while achieving high fidelity results. A detailed description of all models developed in this challenge is provided in this paper.

最近，基于云的图形卷积网络（GCN）在许多对隐私敏感的应用程序（例如个人医疗保健和金融系统）中表现出了巨大的成功和潜力。尽管在云上具有很高的推理准确性和性能，但在GCN推理中保持数据隐私，这对于这些实际应用至关重要，但仍未得到探索。在本文中，我们对此进行了初步尝试，并开发了$ \ textit {cryptogcn} $ - 基于GCN推理框架的同型加密（HE）。我们方法成功的关键是减少HE操作的巨大计算开销，这可能比明文空间中的同行高的数量级。为此，我们开发了一种方法，可以有效利用GCN推断中基质操作的稀疏性，从而大大减少计算开销。具体而言，我们提出了一种新型的AMA数据格式方法和相关的空间卷积方法，该方法可以利用复杂的图结构并在HE计算中执行有效的矩阵矩阵乘法，从而大大减少HE操作。我们还开发了一个合作式框架，该框架可以通过明智的修剪和GCN中激活模块的多项式近似来探索准确性，安全级别和计算开销之间的交易折扣。基于NTU-Xview骨架关节数据集，即，据我们所知，最大的数据集对同型的评估，我们的实验结果表明，$ \ textit {cryptogcn} $均优胜于最先进的解决方案。同构操作的延迟和数量，即在延迟上达到3.10 $ \ times $加速，并将总代态操作数量减少77.4 \％，而准确度的较小精度损失为1-1.5 $ \％$。

深度学习（DL）的快速增长和部署目睹了新兴的隐私和安全问题。为了减轻这些问题，已经讨论了安全的多方计算（MPC），以实现隐私保护DL计算。在实践中，它们通常是在很高的计算和沟通开销中，并有可能禁止其在大规模系统中的受欢迎程度。两种正交研究趋势吸引了人们对安全深度学习的能源效率的巨大兴趣，即MPC比较方案的高架降低和硬件加速度。但是，他们要么达到较低的减少比率，因此由于计算和通信节省有限而遭受了高潜伏期，或者是渴望的，因为现有的作品主要集中在CPU和GPU等一般计算平台上。在这项工作中，作为第一次尝试，我们通过将加密构件构建块的硬件延迟整合到DNN损耗功能中，以实现高能量效率，开发了一个系统的polympcnet，以减少MPC比较协议和硬件加速的联合额外降低的系统框架Polympcnet。和安全保证。我们的关键设计原理不是在DNN进行良好训练之后（通过删除或删除某些非物质操作员）训练（通过删除或删除某些非物质操作员）之后检查模型敏感性，而是要准确地执行DNN设计中的假设 - 培训DNN既是DNN都硬件有效且安全，同时逃脱了当地的最小值和鞍点并保持高精度。更具体地说，我们提出了通过多项式激活初始化方法直接提出的加密硬件友好的可训练多项式激活功能，以替代昂贵的2P-RELU操作员。我们开发了一个密码硬件调度程序和现场可编程门阵列（FPGA）平台的相应性能模型。

通用域的适应性（UNIDA）旨在将公共类的知识从源域转移到目标域，而无需对标签集的任何先验知识，这需要将未知样本与目标域中的已知样本区分开。就像传统的无监督域适应问题一样，由于偏见和歧视性较低的嵌入，两个域之间的错位也存在。最新方法提出了通过将目标样品与最近的邻居或原型聚类来完成域未对准的方法。但是，这样做是很危险的，因为我们对未知样本的分布没有任何先验知识，这些样本可以放大错位，尤其是当未知集很大的时候。同时，其他现有基于分类器的方法可以轻松地产生对未知样本的过度自信预测，因为在源域中有监督的目标导致整个模型偏向于目标域中的共同类别。因此，我们提出了一种新型的非参数未知样品检测方法，基于将原始特征空间中的样品映射到可靠的线性子空间中，这使数据点更稀疏，以减少未知样品和源样本之间的不对准。此外，与最近应用额外参数以改善未知样品分类的方法不同，本文通过未知的自适应保证金损失可以很好地平衡已知样品和未知样品的置信值，从而可以控制分类器学习的梯度在有监督的来源上的梯度更新样品取决于当前步骤中检测到的未知样品的置信度。最后，在四个公共数据集上的实验表明，我们的方法显着胜过现有的最新方法。