In the field of antibody engineering, an essential task is to design a novel antibody whose paratopes bind to a specific antigen with correct epitopes. Understanding antibody structure and its paratope can facilitate a mechanistic understanding of its function. Therefore, antibody structure prediction from its sequence alone has always been a highly valuable problem for de novo antibody design. AlphaFold2, a breakthrough in the field of structural biology, provides a solution to predict protein structure based on protein sequences and computationally expensive coevolutionary multiple sequence alignments (MSAs). However, the computational efficiency and undesirable prediction accuracy of antibodies, especially on the complementarity-determining regions (CDRs) of antibodies limit their applications in the industrially high-throughput drug design. To learn an informative representation of antibodies, we employed a deep antibody language model (ALM) on curated sequences from the observed antibody space database via a transformer model. We also developed a novel model named xTrimoABFold to predict antibody structure from antibody sequence based on the pretrained ALM as well as efficient evoformers and structural modules. The model was trained end-to-end on the antibody structures in PDB by minimizing the ensemble loss of domain-specific focal loss on CDR and the frame-aligned point loss. xTrimoABFold outperforms AlphaFold2 and other protein language model based SOTAs, e.g., OmegaFold, HelixFold-Single, and IgFold with a large significant margin (30+\% improvement on RMSD) while performing 151 times faster than AlphaFold2. To the best of our knowledge, xTrimoABFold achieved state-of-the-art antibody structure prediction. Its improvement in both accuracy and efficiency makes it a valuable tool for de novo antibody design and could make further improvements in immuno-theory.

Learning an explainable classifier often results in low accuracy model or ends up with a huge rule set, while learning a deep model is usually more capable of handling noisy data at scale, but with the cost of hard to explain the result and weak at generalization. To mitigate this gap, we propose an end-to-end deep explainable learning approach that combines the advantage of deep model in noise handling and expert rule-based interpretability. Specifically, we propose to learn a deep data assessing model which models the data as a graph to represent the correlations among different observations, whose output will be used to extract key data features. The key features are then fed into a rule network constructed following predefined noisy expert rules with trainable parameters. As these models are correlated, we propose an end-to-end training framework, utilizing the rule classification loss to optimize the rule learning model and data assessing model at the same time. As the rule-based computation is none-differentiable, we propose a gradient linking search module to carry the gradient information from the rule learning model to the data assessing model. The proposed method is tested in an industry production system, showing comparable prediction accuracy, much higher generalization stability and better interpretability when compared with a decent deep ensemble baseline, and shows much better fitting power than pure rule-based approach.

受到远见与语言之间的牢固联系的启发，我们的论文旨在探索文本中的3D人类全身动作的产生，以及其互惠任务，分别用于文本2Motion和Motion2Text， 。为了应对现有的挑战，尤其是为了使同一文本产生多个不同的动作，并避免了不良生产的琐碎的静止姿势序列，我们提出了使用运动令牌（一种离散和紧凑的运动表示）的使用。当将动作和文本信号视为运动和文本令牌时，这提供了一个级别的游戏地面。此外，我们的Motion2Text模块被整合到我们的文本2Motion训练管道的反对准过程中，在该管道中，合成文本与输入文本的显着偏差将受到较大的培训损失的惩罚；从经验上讲，这证明可以有效地提高性能。最后，通过将神经模型调整为机器翻译（NMT）的两种动作方式和文本之间的映射，可以促进。离散运动令牌上分布的这种自回归建模进一步使来自输入文本的姿势序列（可变长度）的非确定性产生。我们的方法是灵活的，可以用于Text2Motion和Motion2Text任务。在两个基准数据集上进行的经验评估证明了我们在这两个任务上的卓越性能在各种最新方法上。项目页面：https：//ericguo5513.github.io/tm2t/

图形神经网络（GNNS）将深度神经网络（DNN）的成功扩展到非欧几里德图数据，实现了各种任务的接地性能，例如节点分类和图形属性预测。尽管如此，现有系统效率低，培训数十亿节点和GPU的节点和边缘训练大图。主要瓶颈是准备GPU数据的过程 - 子图采样和特征检索。本文提出了一个分布式GNN培训系统的BGL，旨在解决一些关键思想的瓶颈。首先，我们提出了一种动态缓存引擎，以最小化特征检索流量。通过协同设计缓存政策和抽样顺序，我们发现低开销和高缓存命中率的精美斑点。其次，我们改善了曲线图分区算法，以减少子图采样期间的交叉分区通信。最后，仔细资源隔离减少了不同数据预处理阶段之间的争用。关于各种GNN模型和大图数据集的广泛实验表明，BGL平均明显优于现有的GNN训练系统20.68倍。

由于其实际重要性，在提高神经网络安全部署方面的实际重要性，最近经济分配（OOD）检测最近受到了很大的关注。其中一个主要挑战是模型往往会对OOD数据产生高度自信的预测，这在ood检测中破坏了驾驶原理，即该模型应该仅对分布式样品充满信心。在这项工作中，我们提出了反应 - 一种简单有效的技术，用于减少对数据数据的模型过度限制。我们的方法是通过关于神经网络内部激活的新型分析，其为OOD分布显示出高度独特的签名模式。我们的方法可以有效地拓展到不同的网络架构和不同的OOD检测分数。我们经验证明，反应在全面的基准数据集套件上实现了竞争检测性能，并为我们的方法进行了理论解释。与以前的最佳方法相比，在ImageNet基准测试中，反应将假阳性率（FPR95）降低25.05％。

我们的目标是从规定的行动类别中解决从规定的行动类别创造多元化和自然人动作视频的有趣但具有挑战性的问题。关键问题在于能够在视觉外观中综合多种不同的运动序列。在本文中通过两步过程实现，该两步处理维持内部3D姿势和形状表示，Action2Motion和Motion2Video。 Action2Motion随机生成规定的动作类别的合理的3D姿势序列，该类别由Motion2Video进行处理和呈现，以形成2D视频。具体而言，Lie代数理论从事人类运动学的物理法之后代表自然人动作;开发了一种促进输出运动的分集的时间变化自动编码器（VAE）。此外，给定衣服人物的额外输入图像，提出了整个管道以提取他/她的3D详细形状，并在视频中呈现来自不同视图的合理运动。这是通过改进从单个2D图像中提取3D人类形状和纹理，索引，动画和渲染的现有方法来实现这一点，以形成人类运动的2D视频。它还需要3D人类运动数据集的策策和成果进行培训目的。彻底的经验实验，包括消融研究，定性和定量评估表现出我们的方法的适用性，并展示了解决相关任务的竞争力，其中我们的方法的组成部分与最先进的方式比较。

联合学习允许多个参与者在不公开数据隐私的情况下协作培训高效模型。但是，这种分布式的机器学习培训方法容易受到拜占庭客户的攻击，拜占庭客户通过修改模型或上传假梯度来干扰全球模型的训练。在本文中，我们提出了一种基于联邦学习（CMFL）的新型无服务器联合学习框架委员会机制，该机制可以确保算法具有融合保证的鲁棒性。在CMFL中，设立了一个委员会系统，以筛选上载已上传的本地梯度。 The committee system selects the local gradients rated by the elected members for the aggregation procedure through the selection strategy, and replaces the committee member through the election strategy.基于模型性能和防御的不同考虑，设计了两种相反的选择策略是为了精确和鲁棒性。广泛的实验表明，与典型的联邦学习相比，与传统的稳健性相比，CMFL的融合和更高的准确性比传统的稳健性，以分散的方法的方式获得了传统的耐受性算法。此外，我们理论上分析并证明了在不同的选举和选择策略下CMFL的收敛性，这与实验结果一致。

本文提出了一种有效融合多暴露输入并使用未配对数据集生成高质量的高动态范围（HDR）图像的方法。基于深度学习的HDR图像生成方法在很大程度上依赖于配对的数据集。地面真相图像在生成合理的HDR图像中起着领导作用。没有地面真理的数据集很难应用于训练深层神经网络。最近，在没有配对示例的情况下，生成对抗网络（GAN）证明了它们将图像从源域X转换为目标域y的潜力。在本文中，我们提出了一个基于GAN的网络，用于解决此类问题，同时产生愉快的HDR结果，名为Uphdr-Gan。提出的方法放松了配对数据集的约束，并了解了从LDR域到HDR域的映射。尽管丢失了这些对数据，但UPHDR-GAN可以借助修改后的GAN丢失，改进的歧视器网络和有用的初始化阶段正确处理由移动对象或未对准引起的幽灵伪像。所提出的方法保留了重要区域的细节并提高了总图像感知质量。与代表性方法的定性和定量比较证明了拟议的UPHDR-GAN的优越性。

2 Lambda Labs 3 Twitter Figure 1. HoloGAN learns to separate pose from identity (shape and appearance) only from unlabelled 2D images without sacrificing the visual fidelity of the generated images. All results shown here are sampled from HoloGAN for the same identities in each row but in different poses.

This paper proposes Markovian Generative Adversarial Networks (MGANs), a method for training generative neural networks for efficient texture synthesis. While deep neural network approaches have recently demonstrated remarkable results in terms of synthesis quality, they still come at considerable computational costs (minutes of run-time for low-res images). Our paper addresses this efficiency issue. Instead of a numerical deconvolution in previous work, we precompute a feedforward, strided convolutional network that captures the feature statistics of Markovian patches and is able to directly generate outputs of arbitrary dimensions. Such network can directly decode brown noise to realistic texture, or photos to artistic paintings. With adversarial training, we obtain quality comparable to recent neural texture synthesis methods. As no optimization is required any longer at generation time, our run-time performance (0.25M pixel images at 25Hz) surpasses previous neural texture synthesizers by a significant margin (at least 500 times faster). We apply this idea to texture synthesis, style transfer, and video stylization.